中国实用神经疾病杂志2018，Vol.21Issue(3)：310-313,4.DOI:10.12083/SYSJ.2018.03.079
卡左双多巴控释片治疗帕金森病伴发抑郁症临床观察
The curative effect of levodopa in the treatment of Parkinson's disease with depression and its impact on quality of life
摘要
Abstract
Objective To observe the application effect of levodopa in Parkinson accompanied with depression and the influ-ence on the quality of life .Methods A total of 90 patients with Parkinson's disease and depression were prospectively selected and divided into two groups by random number table method ,45 cases in each group .The control group was given placebo on the basis of routine rehabilitation ,exercise therapy and cognitive behavioral therapy ,and the treatment group was given carbidopa and levo-dopa CR tablets .The curative effect for depression ,adverse reactions and quality of life changes of two groups of patients were ob-served .Results The HAMD score of two groups of patients after treatment decreased compared with those before treatment (P<0.05) ,and the degree of reduction of the treatment group was more significant than that of the control group (P<0.05);the total effective rates of the treatment group after four and eight weeks treatment were significantly higher than those of the control group (P<0.05);the adverse reaction rate of treatment group (22.22％ ) was higher than that of the control group (13.33％ ) , but with no significant difference ;the PDQ-39 scores of the two groups showed a downward trend ,while the rank sum test showed that P>0.05 in the control group and P<0.05 in the treatment group .After treatment and at the end of follow-up ,the score of PDQ-39 of the treatment group was significantly lower than that of the control group (P<0.05) .Conclusion Carbidopa/levodopa compound can obviously improve the depressive state of the patients in the short term ,and the curative effect is definite .The ad-verse reactions are less and mild ,and it can improve the quality of life of patients .关键词
卡左双多巴控释片/帕金森病/抑郁/生存质量/运动疗法/认知行为疗法/安慰剂Key words
Levodopa/Parkinson disease/Depression/Curative effect/Quality of life/Exercise therapy/Cognitive behavior therapy/Placebo分类
医药卫生引用本文复制引用
杨怀芹,陆刚,刘阿楠,李华丽..卡左双多巴控释片治疗帕金森病伴发抑郁症临床观察[J].中国实用神经疾病杂志,2018,21(3):310-313,4.基金项目
平顶山市卫生计生委科技惠民项目 （）
