中国实用神经疾病杂志2018，Vol.21Issue(4)：353-356,4.DOI:10.12083/SYSJ.2018.04.090
类固醇生成因子1及细胞角蛋白8在垂体腺瘤中的表达及意义
The expression and role of steroidogenic factor-1 and CK8 in pituitary adenoma
摘要
Abstract
Objective To investigate the role of SF1 and CK8 in the classification of pituitary adenomas .Methods The ex-pressions of SF1 and CK8 in 49 pituitary adenomas were detected by immunohistochemistry .The difference of the expression (SF1 and CK8) in multiple pituitary adenoma were analyzed .Results The rate of SF1 positive staining in gonadotroph adenoma (90％ , 18/20) was significantly higher than that in other pituitary adenoma types (0％ ,0/11) (P<0.01);the rate of CK8 high expres-sion in SF1 immunopositive pituitary adenoma (5/24 ,21％ ) was significantly lower than that in SF1 immunonegative pituitary ad-enoma (23/25 ,92％ ) .Conclusion SF-1 is a key molecular event and play a important role in the diagonosis of gonadotroph adeno-ma .CK8 immunonegative or low expression is one of the molecular characteristics of the gonadotroph adenoma ,and it can be used for the classification of pituitary adenoma .关键词
垂体腺瘤/类固醇生长因子1/细胞角蛋白8/促性腺激素细胞腺瘤/免疫组织化学Key words
Pituitary adenoma/Steroidogenic factor-1/Cytokeratin 8/Gonadotroph adenoma/Immunohistochemistry分类
医药卫生引用本文复制引用
吴会芳,任景丽,王俊宽,常佳,顾斌,冯怡锟,杨婉菁,张岩,胡桂明,陈琛..类固醇生成因子1及细胞角蛋白8在垂体腺瘤中的表达及意义[J].中国实用神经疾病杂志,2018,21(4):353-356,4.基金项目
河南省自然科学基金(162300410307 ) （162300410307 ）
