中国实用神经疾病杂志2018，Vol.21Issue(5)：488-490,3.DOI:10.12083/SYSJ.2018.05.125
癫痫患儿丙戊酸钠血药浓度监测
Serum concentration monitoring of sodium valproate in pediatric epilepsy
摘要
Abstract
Objective To monitor the concentration of plasma with sodium valproate in children with epilepsy ,and provide clinical reference .Methods We used the homogeneous enzyme immunoassay for amplification in 413 children with epilepsy to de-tect serum concentration of sodium valproate ,and the results were analyzed .Results 125 cases had less effective concentration of <50mg/L group (125/413 ,30.3% ) ,268 cases had effective concentration of 50-100mg/L group (268/413 ,64.9% ) ,20 cases had higher than the effective concentration of >100mg/L group (20/413 ,4.8% ) .The serum concentration of sodium valproate in patientunder3yearoldgroup(52.16±22.35)waslowerthanthatofthe3-6yearsoldgroup(61.4±22.11)and >6yearsold group (63.40 ± 23.83) ,the differenceswere statistically significant (P< 0.05) .Conclusion Blood concentration of sodium val-proate varies indifferent individuals ,the dosageshould be adjusted in different age groups .Detection of blood concentration of sodi-um valproate in children with epilepsy can help individual medication ,increase the curative effect ,so as to guide the control of ad-verse reactions ,with practical clinical significance .关键词
癫痫/儿童/丙戊酸钠/血药浓度/基因多态性Key words
Epilepsy/Children/Sodium valproate/Blood concentration/Gene polymorphism分类
医药卫生引用本文复制引用
孙立军..癫痫患儿丙戊酸钠血药浓度监测[J].中国实用神经疾病杂志,2018,21(5):488-490,3.基金项目
福建卫生厅青年课题基金,编号:2013-1-35 （）
