中国实用神经疾病杂志2018，Vol.21Issue(5)：491-495,5.DOI:10.12083/SYSJ.2018.05.126
左乙拉西坦与醒脑静联合重复经颅磁刺激治疗癫痫临床观察
Clinical observation of Levetiracetam and Xingnaojing injection combined with repetitive transcranial magnetic stimulation in the treatment of epilepsy
摘要
Abstract
Objective To investigate the curative effect of Levetiracetam and Xingnaojing injection combined with repetitive transcranial magnetic stimulation in the treatment of patients with epilepsy and its effect on levels changes of serum Intercellular adhesion molecule-1(ICAM-1) and tumor necrosis factor-α(TNF-α) .Methods A total of 114 cases of epileptic patients in our hos-pital from September 2015 to October 2017 were selected and divided into the observation group and the control group by the drawing method ,57 cases in each group .The control group took levetiracetam and Xingnaojing injection ,and the observation group took levetiracetam and Xingnaojing injection combined with repetitive transcranial magnetic stimulation .Both groups were treated for 4 weeks .The clinical effects and the incidence of adverse reactions of two groups were recorded .The cognitive function score (MoCA) and electroencephalogram (the time of sharp wave ,the number of sharp waves) and the levels of serum ICAM-1 and TNF-αin the two groups before and 4 weeks after treatment were compared .Results The total effective rate of the observation group after 4 weeks was 96.49% ,higher than that of the control group (80.70% )(P<0.05) .There wasn't any statistical differ-ence in MoCA score between the two groups before the treatment (P>0.05) .The MoCA score increased after 4 weeks of treat-ment in the two groups ,and the observation group was higher than the control group(P<0.05) .The time of sharp wave and the number of sharp waves of electroencephalogram decreased after 4 weeks of treatment in the two groups ,and the observation group was lower than the control group(P<0.05) .The levels of serum ICAM-1 and TNF-αin the two groups decreased after 4 weeks of treatment ,and the observation group was lower than the control group (P<0.05) .There were insignificant differences in the inci-dence of adverse reactions between the observation group 15.79% and the control group 26.32% (P>0.05) .Conclusion Leveti-racetam and Xingnaojing injection combined with repetitive transcranial magnetic stimulation in the treatment of patients with epi-lepsy can effectively improve the clinical effect ,improve the electroencephalogram and cognitive function ,and reduce the level of serum ICAM-1 and TNF-α.Besides ,it has high safety .关键词
癫痫/左乙拉西坦/醒脑静注射液/重复经颅磁刺激/ICAM-1/TNF-α/认知功能评分Key words
Epilepsy/Levetiracetam/Xingnaojing injection/Repetitive transcranial magnetic stimulation/ICAM-1/TNF-α/Cognitive function score分类
医药卫生引用本文复制引用
赵红艳,郑文权,马建功..左乙拉西坦与醒脑静联合重复经颅磁刺激治疗癫痫临床观察[J].中国实用神经疾病杂志,2018,21(5):491-495,5.基金项目
河南省教育厅科学技术研究重点项目(编号:14A320072) （编号:14A320072）
