中国实用神经疾病杂志2018，Vol.21Issue(5)：499-503,5.DOI:10.12083/SYSJ.2018.05.128
CHA2DS2-VASc评分联合血浆脂蛋白相关磷脂酶A2水平预测非瓣膜病心房颤动患者脑梗死风险的研究
The study of CHA2DS2-VASc score combined with plasma lipoprotein-associated phospholipase A2 levels predic-ting the risk of ischemic stroke in patients with non-valvular atrial fibrillation
摘要
Abstract
Objective To explore the predictive value of CHA2DS2-VASc score combined with plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels for the risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF) .Methods 242 patients with NVAF that were in Affiliated Huizhou Hospital of Guangzhou Medical University were se-lected ,the admission Lp-PLA2 levels was recorded ,and CHA2DS2-VASc score was calculated for each patient .The patients were seen for follow-up visits once every three months after they discharged from hospital ,the follow-up visit finished when the patient suffered ischemic stroke or the patient was followed up for 1 year .They were divided into stroke group and non-stroke group ac-cording to the follow-up result .Results The CHA2DS2-VASc score ,Lp-PLA2 levels of the patient in the stroke group were high-er than that in the non-stroke group .The high CHA2DS2-VASc score and high Lp-PLA2 levels were independent risk factors of ischemic stroke in patients with NVAF by logistic regression analysis .The area under the ROC curve of CHA2DS2-VASc score , Lp-PLA2 levels and CHA2DS2-VASc score combined with Lp-PLA2 levels were 0.815 ,0.796 ,0.895 to predict the happening of ischemic stroke in patients with NVAF .Conclusion CHA2DS2-VASc score combined with Lp-PLA2 levels may improve the pre-dictive value of the risk of ischemic stroke in patients with NVAF .关键词
脂蛋白相关磷脂酶A2/CHA2DS2-VASc评分/非瓣膜病心房颤动/脑梗死/预测价值Key words
Lp-PLA2/CHA2DS2-VASc score/Non-valvular atrial fibrillation/Ischemic stroke/Predictive value分类
医药卫生引用本文复制引用
常保强,马令秋,黄志勇,李乐,张伟,王科,邵升东..CHA2DS2-VASc评分联合血浆脂蛋白相关磷脂酶A2水平预测非瓣膜病心房颤动患者脑梗死风险的研究[J].中国实用神经疾病杂志,2018,21(5):499-503,5.基金项目
广东省医学科研基金立项项目(编号:2016033) （编号:2016033）
