中医药导报2018，Vol.24Issue(4)：83-86,4.
益髓生血颗粒治疗中间型α-地中海贫血及β-地中海贫血的临床观察
Clinical Observation of Yisui Shengxue Granule（益髓生血颗粒）in Treating α-thalassemia and β-thalassemia Intermedia
摘要
Abstract
Objective:To investigate the effects of Yisui Shengxue Granule (YSSXG) in the treatment of α-and β-thalassemia intennedia,make clear of the differences of curative effect.Methods:A total of 68 cases of thalassemia intermedia(42 cases of α-thalassemia,26 cases of β-thalassemia) were observed by the blood index,TCM syndrome score before and after the treatment of YSSXG,analyzed the curative effect of Chinese and Western medicine and its difference between the two types of thalassemia.Results:After YSSXG treatment,Hb and RBC of α-thalassemia increased significantly (P＜0.01),TCM syndrome score decreased significantly(P＜0.01),western medicine efficiency was 81％ (34/42),Chinese medicine efficiency was 71.9％ (23/32).Hb and Ret of β-thalassemia increased significantly (P＜0.05),TCM syndrome score did not significantly decrease (P＞0.05),western medicine efficiency was 61.5％ (16/26),Chinese medicine efficiency was 37.5％ (6/16).The two groups had no significant difference in increasing Hb levels at the end of the treatment,in TCM syndrome score before and after treatment,and in western medicine efficiency (P＞0.05).But at the aspect of improving TCM syndrome and the TCM therapeutic effect,αt-thalassemia are better than β-thalassemia (P＜0.05).Conclusion:There is no significant difference in the efficacy of western medicine in α-and β-thalassemia treating,but there is a significant difference in the efficacy of Chinese medicine.YSSXG not only can effectively improve the Hb level of intermediate α-and β-thalassemia,but also can enhance the RBC level of α-thalassemia and Ret level of β-thalassemia,and significantly improve the TCM syndrome of α-thalassemia,indicating that YSSXG have different efficacy characteristics in the improvement of intermediate α-and β-thalassemia blood index and TCM syndrome.关键词
α-地中海贫血/β-地中海贫血/中间型/益髓生血颗粒/临床观察Key words
α-thalassemia/β-thalassemia/Thalassaemia Intermedia/YiSui ShengXue Granule (YSSXG)/Clinical Observation分类
医药卫生引用本文复制引用
王文娟,吴志奎,张新华,方素萍,刘咏梅,尹晓林..益髓生血颗粒治疗中间型α-地中海贫血及β-地中海贫血的临床观察[J].中医药导报,2018,24(4):83-86,4.基金项目
国家重点基础研究发展计划(973计划,2010CB530406) （973计划,2010CB530406）
国家自然科学基金重大研究计划(90409003) （90409003）
国家自然科学基金(81173167) （81173167）
