基础医学与临床2018，Vol.38Issue(3)：413-417,5.
肠道菌群是高血压干预的新靶点
Gut microbiota might be a new target for the intervention of essential hypertension
摘要
Abstract
The essential hypertension is not only the syndrome but also the main cause of cardio-cerebrovascular disease. Based on analysis of the relations between gut microbiota and the clinical risk factors (glyeolipid metabo-lism disorder,obesity,atherosclerosis) of the essential hypertension, and the research on relationship between gut microbiota and circadian clock disturbance,gut microbiota and central blood pressure regulation,this article illus-trates the changes of the community characteristics of gut microbiota might affect on the occurrence and development of hypertension,also abnormality of the energy absorption,low level of gut derived endotoxin (lipopolysaccharide, LPS) and dysfunction of the gut barrier might play the most important role in this process,moreover,the microbio-ta-gut-brain axis is one of the important approaches.Combining with the increasing evidences which gut microbiota involved in the hypertension control,this article puts forward a viewpoint that gut microbiota might be a new target for the intervention of essential hypertension.关键词
高血压/肠道菌群Key words
essential hypertension/gut microblota分类
医药卫生引用本文复制引用
金华..肠道菌群是高血压干预的新靶点[J].基础医学与临床,2018,38(3):413-417,5.基金项目
国家自然科学基金(81560716) （81560716）
甘肃省自然科学基金(1606RJZA162) （1606RJZA162）
甘肃省高等学校科学研究创新团队项目(2017) （2017）
