基础医学与临床2018，Vol.38Issue(4)：512-515,4.
乳腺癌组织中JARID1B/KDM5B的表达与血液循环肿瘤细胞相关性
Correlation between the expression of JARID1B/KDM5B in breast cancer tissues and the circulating tumor cells
摘要
Abstract
Objective To investigate the relation between expression of JARID1B/KDM5B in invasive breast cancer tissue and circulating tumor cells of invasive breast patients. Methods The S-P immunohistochemical method was used to observe the expression of JARID1B/KDM5B in lesions.imFISH method was used to detect circulation tumor cells. Results Twenty-seven cases of patients showed CTC positive(the number of CTC was more than or equal to 2) in 35 invasive breast cancer cases,The results of JARID1B/KDM5B expression were as follows:(-) (n=0) and (+) in 1 case,(++) in 3 cases,(+++) in 23 cases,8 cases of negative cases (the number of CTC < 2), JARID1B/KDM5B immune group of results:(-) (n=2),(+) in 2 cases,(++) in 1 case,(+++) in 3 cases, The positive relation was found in expression of JARID1B/KDM5B and circulating tumor cells(P<0.05). Conclu-sions JARID1B/KDM5B positive expression in tumor tissues has a certain significance in predicting the recurrence and metastasis of tumor.关键词
JARID1B/KDM5B/浸润性乳腺癌/免疫荧光原位杂交Key words
JARID1B/KDM5B/invasive breast cancer/imFISH分类
医药卫生引用本文复制引用
赵丽华,李秋颖,位嘉,槐英丽,张晓敬,张超,林秋兰,王克杰,闫红燕,郭家良..乳腺癌组织中JARID1B/KDM5B的表达与血液循环肿瘤细胞相关性[J].基础医学与临床,2018,38(4):512-515,4.基金项目
首都特色课题(z171100001017138) （z171100001017138）
