激光生物学报2018，Vol.27Issue(1)：91-96,74,7.DOI:10.3969/j.issn.1007-7146.2018.01.014
周口地区汉族人群26个Y-STR基因座的遗传多态性
Genetic Polymorphisms of 26 Y-STR Loci in Han Population of Zhoukou in Henan Province
摘要
Abstract
This study was to determine the frequencies and parameters of 26 Y chromosomal short tandem repeat loci of Han population from Zhoukou in Henan province. Private alleles of each area were also studied to better explore the ap-plication value of DNATyperY26 kit. Blood samples of 802 non-related male were collected and genotyped through PCR amplification and capillary electrophoresis based on DNATyperY26 kit. Genotype data was then analyzed for allele fre-quencies and parameters. We found 180 alleles with their frequencies ranging from 0.001 ~0.854. Genetic diversity(GD) value of Y-STR loci distributed from 0.261~0.965 with most of them higher than 0.5. Discrimination capacity (DC,0.969) of the kit was very high since 777 haplotypes were detected in 802 samples. The study also showed high haplotype diversity (HD,0.9999). Moreover, we observed 5, 5, 10, 7 private alleles respectively for each area in Zhoukou. In conclusion, DNATyperY26 kit can be widely applied to the research of forensic science and population ge-netics. Analysis of private alleles may benefit in source region inference, which still needs further exploration.关键词
法医遗传学/Y-STR/遗传多态性/私有等位基因Key words
forensic science/Y chromosomal short tandem repeats/genetic polymorphism/private alleles分类
医药卫生引用本文复制引用
尚蕾,莫晓婷,张建,马温华,马新,余政梁,丁光树,王郗..周口地区汉族人群26个Y-STR基因座的遗传多态性[J].激光生物学报,2018,27(1):91-96,74,7.基金项目
公安部技术研究计划(2016JSYJC11,2016JSYJC14) （2016JSYJC11,2016JSYJC14）
北京市现场物证检验工程技术研究中心开放课题(2016CSEEKFKT01) （2016CSEEKFKT01）
中央级公益性科研院所基本科研业务费专项项目(No.2017JB005) （No.2017JB005）
