检验医学与临床2018，Vol.15Issue(6)：750-753,4.DOI:10.3969/j.issn.1672-9455.2018.06.005
VEGF、TNF-α、miR-18a和MCM7在子宫肌瘤组织中的表达及临床意义
Expression and clinical significance of VEGF,TNF-α,miR-18a and MCM7 in uterine myoma tissues
摘要
Abstract
Objective To analyze the expression and clinical significance of VEGF,TNF-α,miR-18a and MCM7 in uterine myoma tissues.Methods The expression of VEGF,TNF-α,MCM7,PR and ER in 43 cases of uterine myoma tissues and normal uterine myometrial tissues were detected by immunohistochemistry,the expression of miR-18a was detected by situ hybridization method.The expression results were compared and analyzed.Results The positive rates of VEGF,TNF-α,MCM7,PR and ER in uterine myoma tissues were sig-nificantly higher than those in normal uterine myometrial tissues,the miR-18a positive rates was significantly lower than that in normal uterine myometrial tissues(P< 0.05);the Spearman correlation analysis results showed that the levels of PR and ER had significantly positive correlation with the levels of VEGF,TNF-α and MCM7,and had significant negative correlation with the miR-18a level;the positive rates of VEGF,TNF-α and MCM7 were gradually elevated with the tumor enlargement and tumor number increase,while the miR-18a positive rate was gradually decreased.Conclusion VEGF,TNF-α,MCM7 and miR-18a abnormal expression may play an important role in the occurrence and development of uterine myoma.关键词
血管内皮生长因子/肿瘤坏死因子-α/微小核糖核酸-18a/微小染色体维持蛋白7/子宫肌瘤Key words
vascular endothelial grow th factor/tumor necrosis factor-α/microRNA-18a/minichro-mosome maintenance protein 7/uterine myoma分类
医药卫生引用本文复制引用
张冬红,刘恩令..VEGF、TNF-α、miR-18a和MCM7在子宫肌瘤组织中的表达及临床意义[J].检验医学与临床,2018,15(6):750-753,4.基金项目
河北省卫生和计划生育委员会课题(20160850). （20160850）
