检验医学与临床2018，Vol.15Issue(6)：772-774,3.DOI:10.3969/j.issn.1672-9455.2018.06.011
重组活化凝血因子Ⅶ对自发性脑出血患者的疗效分析
Analysis on curative effect of recombinant activated blood coagulation factor Ⅶin patients with spontaneous intracerebral hemorrhage
鲍渝霞 1高荐辕2
作者信息
- 1. 昆明医科大学第一附属医院医学检验科/云南省实验诊断研究所/云南省检验医学重点实验室,昆明650032
- 2. 昆明医科大学第一附属医院血管外科,昆明650032
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of recombinant activated factor Ⅶ(rFⅦa)in the treatment of spontaneous intracerebral hemorrhage.Methods One hundred and twenty-eight cases of spontaneous intracerebral hemorrhage treated in this hospital were collected as the study subjects and randomly divided into the control group(59 cases)and observation group(69 cases).The control group was given the routine liquid infusion therapy plus ethamsylate;while on this basis the observation group was added with rFⅦa therapy.The change of hematoma volume was evaluated by using CT plain scanning after 24 h treatment.The NIHSS score was used to evaluate the recovery situation of the two groups after 3,7 d treat-ment.The Rankin scale(mRS)and ADL scores were used to evaluate the long term prognosis on 30,90 d after treatment;the occurrence situation of adverse reactions in the two groups during the therapeutic process was recorded.Results After 24 h treatment,the enlarged volume of hematoma in the observation group was less than that in the control group,the difference between them was statistically significant(P<0.05);the symp-toms after 3,5 d treatment in the two groups were significantly improved,the NIHSS score in the observation group was significantly better than that in the control group,the difference between the two groups was statis-tically significant(P<0.05);after 90 d treatment,the mRS score and ADL score in the observation group were better than those in the control group,the differences were statistically significant(P<0.05);the adverse re-actions had no statistically significant difference between the two groups(P>0.558).Conclusion rFⅦa has significant effect for treating spontaneous cerebral hemorrhage,can effectively improve the recovery of neurological function and does not increase the incidence of adverse reactions,and is a safe and effective treatment method.关键词
重组活化凝血因子Ⅶ/自发性/脑出血/美国国立卫生院卒中量表评分Key words
rFⅦa/spontaneous/intracerebral hemorrhage/NIHSS分类
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鲍渝霞,高荐辕..重组活化凝血因子Ⅶ对自发性脑出血患者的疗效分析[J].检验医学与临床,2018,15(6):772-774,3.
