兰州大学学报（医学版）2018，Vol.44Issue(1)：7-13,7.DOI:10.13885/j.issn.1000-2812.2018.01.002
生物标志物NGAL、NAG、胱抑素C诊断对比剂急性肾损伤的价值
Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for contrast-induced nephropathy after coronary angiography
摘要
Abstract
Objective To determine urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a biomarker for early detection of acute kidney injury.Methods Patients from five centers undergoing coronary angiography with contrast medium exposure were prospectively enrolled.Serial urine samples were prospectively obtained from all patients at baseline,2,6,12,24,48 and 72 h after CAG,and serum samples were collected too.Urinary NGAL and NAG,serum cretinine and cystatin C were measured and analyzed.CI-AKI was diagnosed in 17 patients (CI-AKI group) and 17 patients without CI-AKI matched with the CI-AKI subjects were selected into control group.Results Urinary NGAL levels were significantly increased in the CI-AKI group at 2,6,12,24 h after CAG compared with the baseline,and 2 h and 6 h-uNGAL differed significantly between CI-AKI and non-CI-AKI group.The predictive power ofuNGAL was demonstrated by area under the receiveroperating characteristics curve for diagnosis of CI-AKI at 6,12 h after CAG was 0.713 and 0.772,respectively.Urinary NAG showed no difference between CI-AKI and non-CI-AKI groups at any time-point.Serum creatinine in CI-AKI group differed significantly 48 and 72 h after CAG compared with non-CI-AKI group,and serum cystatin C differed significantly 72 h after CAG compared with non-CI-AKI group.Conclusions Urinary NGAL is an early biomarker for CI-AKI,which facilitates the diagnosis of CI-AKI.Serum crerinine or cystatin C is not good marker for the early detection of CI-AKI.关键词
尿中性粒细胞明胶酶相关载脂蛋白/尿N-乙酰-β-D氨基葡萄糖苷酶/对比剂急性肾损伤/生物标志物/早期诊断Key words
urinary neutrophil gelatinase-associated lipocalin/N-acetyl-β-D-glucosaminidase/contrast-induced nephropathy/biomarker/early diagnosis分类
医药卫生引用本文复制引用
张翩,牟姗,倪兆慧,王玲,何奔,王肖龙,邱建平,郑昌柱,杨光敏,庞慧华,沈剑箫..生物标志物NGAL、NAG、胱抑素C诊断对比剂急性肾损伤的价值[J].兰州大学学报（医学版）,2018,44(1):7-13,7.基金项目
浦东新区科技发展基金创新资金项目(PKJ2009-Y12) （PKJ2009-Y12）
上海市重大科研项目(08DZ1900500) （08DZ1900500）
上海市卫计委综合医院中西医结合专项(2015-2017年)重点项目(ZHYY-ZXYJHZX-1-02) （2015-2017年）
国家自然科学基金项目(81370794 （）
81570604) （）
上海市卫生和计划生育委员会科研项目(20134095) （20134095）
