临床肝胆病杂志2018，Vol.34Issue(3)：649-652,4.DOI:10.3969/j.issn.1001-5256.2018.03.047
沉默调节蛋白1在非酒精性脂肪性肝病发生发展中的作用
Role of silent information regulator 1 in development and progression of nonalcoholic fatty liver disease
摘要
Abstract
Silent information regulator 1(SIRT1),a member of the Sirtuin family,is a deacetylase depending on nicotinamide adenine di-nucleotide and is mainly involved in energy metabolism,cell survival,aging,and apoptosis. Nonalcoholic fatty liver disease(NAFLD)is a chronic liver disease closely related to insulin resistance,oxidative stress,and lipid peroxidation. This article elaborates on the association of SIRT1 with energy metabolism,oxidative stress,lipid peroxidation,and endoplasmic reticulum stress and points out that SIRT1 is closely as-sociated with the development and progression of NAFLD.关键词
非酒精性脂肪性肝病/沉默调节蛋白-1/胰岛素抵抗/内质网应激/综述Key words
non - alcoholic fatty liver disease/silent information regulator transcription 1/insulin resistance/endoplasmic reticulum stress/review分类
医药卫生引用本文复制引用
杨帅..沉默调节蛋白1在非酒精性脂肪性肝病发生发展中的作用[J].临床肝胆病杂志,2018,34(3):649-652,4.基金项目
国家自然科学基金重点项目(81430014) （81430014）
国家自然科学基金面上项目(31370917) （31370917）
