临床口腔医学杂志2018，Vol.34Issue(3)：145-149,5.DOI:10.3969/j.issn.1003-1634.2018.03.005
舌鳞状细胞癌相关差异基因的生物信息学及预后分析
Bioinformatics and prognostic analysis of differential genes related totongue squamous cell carcinoma
高桂林 1朱斌 1颜孟雄1
作者信息
- 1. 恩施土家族苗族自治州中心医院口腔诊疗中心 湖北 恩施 445000
- 折叠
摘要
Abstract
Objective:Using the bioinformatics method based on GEO and TCGA databases to exploit the develop-ment of the molecular markers oftongue squamous cell carcinoma and to analyze the prognosis.Methods:Download TSCC re-lated chip data from the GEO database.GEO2 R was used to screen differentially expressed genes,then GO and KEGG were used to analyze the function and pathway enrichment of differentially expressed genes.At the same time,the interaction net-work is constructed by using STRING and Cytoscape software and Hub geneswere screened.The prognosis of Hub genes were analyzed with clinical information attached to TCGA database. Results:Totally 861 differentially expressed genes were screened outwhich 342 were up regulated and 519 down regulated. GO,KEGG analysis and protein interaction network screening showed VEGFA,ITGA3,COL1 A1 and COL17 A1 as Hub gene. Survival analysis showed that high expression VEGFA and ITGA3 were risk factors for prognosis.Conclusion:VEGFA,ITGA3 can be used as biomarker associate with de-veloping and prognosis of TSCC and were expected to provide the basis for the further study of TSCC.关键词
舌鳞状细胞癌/生物信息学/差异表达基因/预后Key words
Tongue squamous cell carcinoma/Bioinformatics/Differentially expressed gene/Prognosis分类
医药卫生引用本文复制引用
高桂林,朱斌,颜孟雄..舌鳞状细胞癌相关差异基因的生物信息学及预后分析[J].临床口腔医学杂志,2018,34(3):145-149,5.
