国际眼科杂志2018，Vol.18Issue(1)：63-67,5.DOI:10.3980/j.issn.1672-5123.2018.1.14
国产小牛血去蛋白提取物眼用凝胶对角膜屈光术后角膜上皮修复的Meta分析
Meta analysis of therapeutic effects of domestic deproteinized calf blood extract eye gel on corneal epithelial repair after laser refractive surgery
张健 1杨伊琳 2黄海帆3
作者信息
- 1. 515000 中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心角膜眼表及白内障科
- 2. 515000 中国广东省汕头市中心医院儿科
- 3. 515000 中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心眼底科
- 折叠
摘要
Abstract
AIM:To systemically evaluate the clinical efficacy and safety of domestic deproteinized calf blood extract eye gel for corneal epithelial repair after laser refractive surgery.METHODS:We performed a comprehensive search via Pubmed,Embase,Cochrane Library,VIP Chinese Science and Technology Journal Database,CNKI and Wan Fang Chinese periodical Database for the randomized controlled trials(RCTs) at home and abroad about effects of the domestic deproteinized calf blood extract eye gel for corneal epithelial repair after laser corneal refractive surgery with retrieval time from January 2007 to December 2016.According to the inclusion and exclusion criteria,2 medical researchers independently screened documents,extracted data and evaluated the quality.Review Manager 5.3 software was used for Meta analysis.RESULTS:Seven RCTs involving 1042 eyes,including 523 eyes in the treatment group and 519 eyes in the control group,were selected for this Meta-analysis.The results showed that the clinical efficacy in the treatment group was better than that in the control group (OR=1.81,95％CI:1.39 ～2.35;P＜0.001).And the corneal injury symptom score in the treatment group was superior to that in the control group (WMD=-0.33,95％CI:-0.45 to-0.21;P＜0.001).And the corneal healing time in the treatment group was shorter than that in the control group (WMD=-1.26,95％CI:-1.56 to-0.97;P＜0.001).CONCLUSION:The domestic deproteinized calf blood extract eye gel can relieve the patients' symptoms after laser refractive surgery,improve the corneal epithelial recovery and the efficiency of treatment.Due to the limited quality and quantity of the studies these conclusions should be further validated by more welldesigned randomized double blind controlled trials.关键词
角膜上皮修复/准分子激光屈光手术/小牛血去蛋白提取物眼凝胶/随机对照/Meta分析Key words
corneal epithelial repair/laser refractive surgery/deproteinized calf blood extract eye gel/randomized controlled/Meta-analysis引用本文复制引用
张健,杨伊琳,黄海帆..国产小牛血去蛋白提取物眼用凝胶对角膜屈光术后角膜上皮修复的Meta分析[J].国际眼科杂志,2018,18(1):63-67,5.
