国际眼科杂志2018，Vol.18Issue(1)：140-142,3.DOI:10.3980/j.issn.1672-5123.2018.1.34
不同分期糖尿病视网膜病变患者外周血中AT-Ⅲ、PAI、t-PA变化的研究
Research on AT-Ⅲ, PAI and t-PA in patients with different stages of diabetic retinopathy
摘要
Abstract
AIM:To explore the relationship between the different stages of diabetic retinopathy and the related factors of vascular endothelial function,and to provide a theoretical basis for improving the function of vascular endothelium to find a way to delay or even inhibit the occurrence or progression of DR.METHODS:We collected during March 2015 to December 2015 in Department of Ophthalmology and endocrinology in our hospital,178 cases of type 2 diabetes mellitus patients and 62 cases of blood specimen in health control group.According to the results of fundus fluorescence angiography (FFA),they were divided into four groups,diabetes patients without retinopathy,diabetes patients with non proliferative diabetic retinopathy (NPDR),diabetes patients with proliferative diabetic retinopathy (PDR) and healthy control group.We detected blood samples of antithrombin Ⅲ (AT-Ⅲ),fibrinolytic enzyme activation inhibitor (PAI),the original organization type fibrinolytic enzyme activator (t-PA) index and the correlation of diabetic retinopathy in installment.RESULTS:This study showed that AT-Ⅲ was significantly different among the four groups (F=5.986,P＜ 0.01);PAI was significantly different among the patients without DR,patients with NPDR and patients with PDR (F=7.434,P＜0.01);t-PA was not significantly different among the four groups (F=2.556,P＞ 0.05);there were relations between the different stages of diabetic retinopathy and AT-Ⅲ,PAI.CONCLUSION:The degree of diabetic retinopathy has a close relationship with the content of antithrombin Ⅲ and plasminogen activator inhibitor,and it is closely related to the function of vascular endothelium.关键词
糖尿病视网膜病变/血管内皮因子/糖尿病视网膜病变分期Key words
diabetic retinopathy/vascular endothelial factor/diabetic retinopathy staging引用本文复制引用
姜璐璐,于春霞,热娜古丽·艾则孜,穆塔里甫..不同分期糖尿病视网膜病变患者外周血中AT-Ⅲ、PAI、t-PA变化的研究[J].国际眼科杂志,2018,18(1):140-142,3.基金项目
国家自然科学基金项目(No.81360149)National Natural Science Foundation of China (No.81360149) （No.81360149）
