南京医科大学学报（自然科学版）2018，Vol.38Issue(2)：195-200,6.DOI:10.7655/NYDXBNS20180210
Wnt信号通路与mCRC含伊立替康化疗疗效及预后的易感性研究
Wnt signaling pathway and the susceptibility of curative effect and prognostic of mCRC patients received irinotecan-based chemotherapy
摘要
Abstract
Objective:To explore the association between single nucleotide polymorphisms (SNPs)in the Wnt signaling pathway genes and the curative effect and prognostic of metastatic colorectal cancer (mCRC)patients who received irinotecan-based chemotherapy.Methods:We selected seven key genes in the Wnt signaling pathway and genotyped the SNPs within seven genes among 110 mCRC patients treated with irinotecan-based chemotherapy.Logistic regression and cox regression analysis were performed to evaluate the association between SNPs and the curative effect and prognostic of mCRC patients.Results:Patients with the LRP6 rs10772542 C alleles had a lower disease control rate (DCR)compared with those with T alleles (OR=2.49,95％CI=1.28～4.83,P=0.007).LEF1 rs749414 G alleles had a longer progression-free survival (PFS)compared with the T alleles (HR=0.55,95％ CI=0.40～ 0.78,P=0.001)and WNT7B rs10448605 T alleles had a shorter PFS compared with the C alleles (HR=1.65,95％CI=1.13～2.41,P=0.009).Furthermore,WNT2 rs2239957 C alleles had a longer overall survival (OS)compared with the G alleles (HR=0.54,95％CI=0.35～0.85,P=0.007).Conclusion:Genetic variants in the Wnt signaling pathway genes contribute to the curative effect and prognostic of mCRC patients who received irinotecan-based chemotherapy.关键词
Wnt信号通路/mCRC/伊立替康Key words
Wnt signaling pathway/metastatic colorectal cancer/irinotecan分类
医药卫生引用本文复制引用
曹玲,谢利生,黎书炜,杜牧龙,顾冬英,张正东,王美林..Wnt信号通路与mCRC含伊立替康化疗疗效及预后的易感性研究[J].南京医科大学学报（自然科学版）,2018,38(2):195-200,6.基金项目
国家自然科学基金(81773516) （81773516）
江苏省高校优势学科建设资助(公共卫生与预防医学) （公共卫生与预防医学）
