南京医科大学学报（自然科学版）2018，Vol.38Issue(2)：277-282,6.DOI:10.7655/NYDXBNS20180231
对混合性毛玻璃样结节和单纯性毛玻璃样结节的临床Ⅰ期非小细胞肺癌患者进行淋巴结转移率比较的Meta分析
Metastatic rate of lymph nodes in clinical stage Ⅰ non-small-cell lung cancer patients with mixed ground-glass opacity versus pure ground-glass opacity: Meta-analysis
摘要
Abstract
Objective:This systematic review and Meta-analysis aimed to investigate the metastatic rate of hilar lymph node and mediastinal lymph node in clinical stage Ⅰ non-small-cell lung cancer patients with either pure ground-glass opacity (Pure-GGO)or mixed ground-glass opacity (Mixed-GGO),therefore to indicate how to dissect lymph nodes in patients with GGO.Methods:A systematic search of the published literature was conducted using the main databases (Science Direct,PubMed,Springer Link and Wiley Online Library)to collect relevant case-control studies that compared Pure-GGOs and Mixed-GGOs in clinical stage Ⅰ non-small-cell lung cancer patients.Meta-analysis was performed extracting data from the published literature using STATA 12.0.The results of the Meta-analysis were expressed as an odds ratio (OR)and their corresponding 95％ confidence interval (CI).Results:We extracted data from three case-control studies,with a total of 736 patients.There was no significant difference (OR=3.66,95％ CI:0.68-19.58,P=0.13) in the rates of metastases in all lymph nodes in patients with either Pure-GGO or Mixed-GGO.In addition,there were no significant differences (OR=4.22,95％ CI:0.77-23.19,P=0.10)in the rates of metastases in hilar lymph nodes in patients with either Pure-GGO or Mixed-GGO,but one study showed an OR of 20.18 (95％ CI:0.94-432.12).There was no significant difference in rates of metastases of mediastinal lymph nodes in patients with either Pure-GGO or Mixed-GGO (OR=1.10;95％ CI:0.19-6.32,P=0.92).Conclusion:The results indicated no statistically significant difference in metastatic rates of hilar lymph nodes and mediastinal lymph nodes in patients with either Pure-GGO or Mixed-GGO.However,as thoracic surgeon,we must be particularly cautious about metastasis in hilar lymph nodes in patients with Mixed-GGO.关键词
单纯性GGO/混合性GGO/淋巴结转移率/Meta分析Key words
Pure-GGO/Mixed-GGO/metastatic rate of lymph nodes/Meta analysis分类
医药卫生引用本文复制引用
赵飞,徐剑霞,蒋婷,张智轩,孙锦鹏,王伟..对混合性毛玻璃样结节和单纯性毛玻璃样结节的临床Ⅰ期非小细胞肺癌患者进行淋巴结转移率比较的Meta分析[J].南京医科大学学报（自然科学版）,2018,38(2):277-282,6.基金项目
江苏省自然科学基金(BK20151589) （BK20151589）
