四川医学2017，Vol.38Issue(12)：1392-1396,5.DOI:10.16252/j.cnki.issn1004-0501-2017.12.010
冠心病患者血尿酸水平与冠状动脉病变程度的相关性研究
Study on the Correlation between Serum Uric Acid and Severity of Coronary Artery Disease in Patients with Coronary Heart Disease
袁宁 1刘雅 2彭春梅 2王晓娟 1杨文翔1
作者信息
- 1. 南充市中心医院内分泌科,四川南充637000
- 2. 成都市第二人民医院老年科,四川成都610017
- 折叠
摘要
Abstract
Objective To investigate the correlation between serum uric acid level and severity of coronary artery disease in patients with coronary heart disease.Methods The serum uric acid level of 202 patients with coronary heart disease and 50 patients with non-coronary heart disease (control group) was measured,at same time the severity of coronary artery disease was assessed by Gensini score.The patients with coronary heart disease were divided into four groups according to the quartile of serum uric acid level:the first quartile group(n =50),the second quartile group (n =51),the third quartile group (n =49),the fourth quartile group(n =52).The general information and coronary angiography results were compared between 5 groups.Results The detection rate of carotid artery plaque,HDL-C,uric acid (UA) and Gensini score were statistically significant between 5 groups (P ＜ 0.05),and the detection rate of multi-vessel disease in the fourth quartile was significantly higher than that of control group and the first quartile group (P ＜ 0.05).Correlative analysis revealed that blood UA was still positively correlated with Gensini score (r =0.148,P =0.023)after the effects of the age and sex were controlled.Linear regression analysis revealed that UA was associated with Gensini scores in patients with coronary heart disease and multivariate stepwise regression analysis suggested that UA was an independent risk factor for Gensini score (b =0.159,P =0.037).Conclusion Serum uric acid is positively correlated with Gensini score in patients with Coronary heart disease.The level of serum uric acid in patients with coronary heart disease is an important independent indicator of the severity of coronary artery disease.关键词
冠心病/血清尿酸/Gensini评分/冠状动脉造影Key words
coronary heart disease/serum uric acid/Gensini score/coronary angiography分类
医药卫生引用本文复制引用
袁宁,刘雅,彭春梅,王晓娟,杨文翔..冠心病患者血尿酸水平与冠状动脉病变程度的相关性研究[J].四川医学,2017,38(12):1392-1396,5.
