摘要
Abstract
Objective To investigate the physiological changes of thyroid stimulating hormone (TSH),free Triiodothym nine(FT3)and free Thyroxine(FT4)in early,middle and late stage of pregnancy,and the necessity of detecting thyroid hormone during pregnancy.Methods 289 cases of pregnant women are included,consisting of 89 cases if T1 stage (gestational week ＜ 12w),159 cases of T2 stage(gestational week between 13w and 28w)and 41 cases of T3 stage(gestational week ＞28w),46 cases of healthy non-pregnant women as control group.Roche E601 electrochemiluminescence analyzer was used to determine TSH,FT3 and FT4 level of research objects and do statistical analysis.Results Among these research objects,there was 1 case of clinical hyperthyroidism,accounting for 0.3％ and the morbidity of gestational hypothyroidism was 8.65％,including 3 cases of clinical hypothyroidism,accounting for 1.03％ and 22 cases of subclinical hypothyroidism,accounting for 7.61％.TSH level during pregnancy gradually rose from (1.23 ± 0.77) of T1 stage to (2.33 ± 1.28) of T2 stage and then to (2.21 ± 1.03) of T3 stage,while FF 3 and FT4 presented a downtrend.TSH level of T1 stage was significantly lower than that of control group(2.59 ± 0.90),while there was no statistically significant difference between the two as for FT3 and FT4.TSH level of T2 stage presented no statistically significant difference with that of T3 stage,contrary to the results of FT3 and FT4.Conclusion Thyroid hormone of women in either stage of pregnancy has difference with healthy non-pregnant women and reference interval of thyroid hormone in each stage of pregnancy should be established.Morbidity of hypothyroidism in pregnant women is higher than non-pregnant women of the same age,so there is necessity to screen thyroid function to promote Eugenics.关键词
妊娠期/甲状腺激素/甲状腺功能减退症Key words
pregnancy/thyroid hormone/hypothyroidism分类
医药卫生
