世界中医药2018，Vol.13Issue(2)：325-328,4.DOI:10.3969/j.issn.1673-7202.2018.02.018
益气活血方联合四联疗法治疗幽门螺杆菌阳性的慢性萎缩性胃炎的疗效及对胃蛋白酶原的影响
Clinical Effects of Yiqi Huoxue Fang Combined with Quadruple Therapy on Helicobacter Pylori Positive Chronic Atrophic Gastritis and Its Effects on Pepsinogen
王永增 1马艳荣 2刘玉生 1司雁菱 1张建博 1孙岭3
作者信息
- 1. 唐山工人医院分院消化内科,唐山,063000
- 2. 解放军第255医院肿瘤内科,唐山,063000
- 3. 唐山工人医院分院中医科,唐山,063000
- 折叠
摘要
Abstract
Objective:To discuss the effects of Yiqi Huoxue Fang combined with quadruple therapy on chronic atrophic gastritis (CAG)of helicobacter pylori(HP)positive stomach body in the type of spleen and stomach qi deficiency and blood stasis type di -agnosed by Chinese medicine discrimination and its effects on pepsinogen(PG)and inflammatory factors.Methods:A total of 87 cases of Hp positive CAG admitted and treated in Tangshan Workers'Hospital from May 2013 to October 2016 were randomly di-vided into experimental group(n=45)and control group(n=42).The control group was treated with quadruple therapy,and the experimental group treated by Yiqi Huoxue Fang combined with quadruple therapy.PG test was performed before treatment(day 0) and after treatment(day 40)in the two groups.The clinical curative effect of the two groups and the changes of PG and inflamma-tory factors were compared.Results:After treatment,the effective rate of the experimental group was 84.44%,which was signifi-cantly higher than 64.29%of the control group(P<0.05).After treatment,PGⅠ content and PGⅠ/PGⅡ were significantly higher than those before treatment(P<0.05 or P<0.01),and the experimental group was significantly higher than the control group(P<0.05 or P<0.01);the contents of PGⅡin two groups had not significantly changed compared with those before treat-ment(P>0.05),and there was no difference between the two groups(P>0.05); after treatment,IL-6,TNF-αand CRP of the two groups were significantly lower than those before treatment(P<0.01),and the experiment group was lower than the control group(P<0.01).Conclusion:Yiqi Huoxue Fang combined with quadruple therapy can improve the main clinical symptoms of Hp positive CAG patients,enhance the secretion of gastric mucosa,improve the content of PG in serum and reduce the level of inflam-matory factors,which was safe and effective and worthy of clinical application.关键词
幽门螺杆菌阳性/慢性萎缩性胃炎/益气活血方/四联疗法/胃蛋白酶原Key words
Helicobacter pylori positive/Chronic atrophic gastritis/Yiqi Huoxue Fang/Quadruple therapy/Pepsinogen分类
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王永增,马艳荣,刘玉生,司雁菱,张建博,孙岭..益气活血方联合四联疗法治疗幽门螺杆菌阳性的慢性萎缩性胃炎的疗效及对胃蛋白酶原的影响[J].世界中医药,2018,13(2):325-328,4.
