世界中医药2018，Vol.13Issue(2)：428-432,5.DOI:10.3969/j.issn.1673-7202.2018.02.045
阿萨伊对虚热证大鼠神经递质、三长轴激素及环核苷酸的影响
Effects of Acaí(Euterpe oleracea)on Neurotransmitter,Triaxial Hormone and Cyclic Nucleotide in Rats with Deficiency Heat Syndrome
摘要
Abstract
To study the effects of Acaíon neurotransmitter,triaxial hormone and cyclic nucleotide in rats with deficiency heat syn-drome and to discuss the drug property of cold and heat.All the SD rats were divided into blank group,deficiency-heat model group,deficiency-heat +Cortex Phellodendri group,deficiency-heat +Acaíhigh dose and low dose groups.The model rats were prepared by using daily intramuscular injection of dexamethasone sodium phosphate with continuous injection for 21 days.The changes of neurotransmitter(NE,DA,5-ht),hormones(T4,T3,CORT,E2,T)and cyclic nucleotide(cAMP and cGMP)were de-tected by enzyme-free method and free-release method.The level of NE,DA,T4,T3,E2,cAMP and cGMP in serum were signifi-cantly decreased in the Aca íhigh dose group(P<0.05,P<0.001,P<0.001,P<0.01,P<0.001,P<0.001,P<0.001).The levels of 5-HT,CORT and T in serum were significantly increased in the Aca íhigh dose group(P<0.001,P<0.05,P<0.05). The Acaíshowed the same effect with Cortex Phellodendri and Gegen Qinlian Decoction in adjusting the levels of deficiency -heat rats.This experiment verified a comparative pharmacological method to derive the drug property of cold and heat of Asai.关键词
阿萨伊/虚热证/虚寒证/神经递质/激素/环核苷酸/中药药性Key words
Acaí/Deficiency-heat syndrome/Neurotransmitter/hormone/Cyclic nucleotide/Chinese herbal properties分类
医药卫生引用本文复制引用
王子晨,王林元,朱映黎,瞿研,王佳,费文婷,张建军,熊平..阿萨伊对虚热证大鼠神经递质、三长轴激素及环核苷酸的影响[J].世界中医药,2018,13(2):428-432,5.基金项目
北京中医药大学自主课题(2015-JYB-XS002) （2015-JYB-XS002）
北京中医药大学自主课题(2016-JYB-JSPY-013) （2016-JYB-JSPY-013）
广东省科技计划项目(2014A070713031) （2014A070713031）
