天然产物研究与开发2018，Vol.30Issue(2)：207-211,256,6.DOI:10.16333/j.1001-6880.2018.2.006
不同大鼠模型探讨连翘挥发油解热、抗炎作用
Antipyretic and Anti-inflammatory Effects of Forsythia suspense Volatile Oil in Different Rats Models
摘要
Abstract
To investigate the effects of volatile oil of Forsythia suspense (VOFF) on different rat models,and explore the mechanism of its anti-inflammatory and antipyretic effects.Two rat fever models were established by subcutaneously injection of dry yeast and intraperitoneal injection of lipopolysaccharide (LPS) to evaluate the antipyretic effect of VOFF,respectively.Rats cotton ball granuloma model,rats foot swelling model induced by subcutaneous injection of carrageen or fresh egg white at the right posterior foot were used to evaluate the anti-inflammatory effects.VOFF can significantly inhibit LPS and dry yeast induced fever,reduce carrageenan and fresh egg white induced rat paw edema,compared with the model group (P ＜ 0.05).It can also significantly inhibit the proliferation of granulation tissue,compared with the model group (P ＜0.01).The results showed that VOFF had obvious antipyretic and anti-inflammatory effects,which provided a theoretical basis for further research on heat clearing and detoxifying function.关键词
连翘挥发油/清热解毒/解热/抗炎Key words
volatile oil of Forsythia suspense/heat clearing and detoxifying/antipyretic/anti-inflammatory分类
医药卫生引用本文复制引用
罗林,袁岸,党珏,赵梦杰,李芸霞..不同大鼠模型探讨连翘挥发油解热、抗炎作用[J].天然产物研究与开发,2018,30(2):207-211,256,6.基金项目
国家自然科学基金面上项目(81373943,81573583) （81373943,81573583）
四川省科技厅省青年科技创新研究团队专项计划(2016TD0006,2017TD0001) （2016TD0006,2017TD0001）
