天然产物研究与开发2018，Vol.30Issue(2)：304-309,6.DOI:10.16333/j.1001-6880.2018.2.022
松节方提取物对炎症动物模型的抗炎作用及机制探讨
Anti-inflammatory Effect and Mechanism of SongJieFang Extract in Animal Inflammation Models
摘要
Abstract
The aim of this study was to evaluate the anti-inflammatory and analgesic effects of SongJieFang (SJF) extracts,especially the inhibitory effect on rheumatoid arthritis,and to explore its mechanism.Three artificially induced models were used to evaluate the effects,including Murine Ear Edema Model induced by xylene,Murine Pain Model induced by acetic acid and Rat Rheumatoid Arthritis Model induced by chicken collagen Ⅱ.The levels of TNF-α,INF-γ,IL-10 and IL-1β in serum were detected and the histopathological changes of the ankle joint were observed.The results showed that SJF extract can reduce the inflammation and pain of the above model,inhibit the inflammatory cell infiltration and tissue hyperplasia in synovium in Rat Rheumatoid Arthritis Model,and significantly decrease the serum TNF-α and INF-γ,IL-1β levels,but increased serum IL-10 levels.These results suggested that SJF extract can inhibit the arthritis in Rat Rheumatoid Arthritis Model and reduce the degree of joint injury.The mechanism may be related to the regulation of inflammatory factor expression.关键词
关节炎/松节方/提取物/抗炎/机制Key words
rheumatoid arthritis/SongJieFang/extract/anti-inflammation/mechanism分类
医药卫生引用本文复制引用
莫宗成,梅小利,黄文涛,吴思澜,王敏,黄崇刚..松节方提取物对炎症动物模型的抗炎作用及机制探讨[J].天然产物研究与开发,2018,30(2):304-309,6.基金项目
重庆市科委基本业务费项目(2015cstc-jbky-01908) （2015cstc-jbky-01908）
