天然产物研究与开发2018，Vol.30Issue(2)：332-338,7.DOI:10.16333/j.1001-6880.2018.2.026
香豆素类化合物的抑菌活性研究
The Advances on Antibacterial Activity of Coumarins
摘要
Abstract
Coumarins are naturally derived compounds fused benzene and α-pyrone rings which are found in large range of plant sources.Recently,several studies have been conducted on the biological activity of coumarins,such as anticancers,anti-inflammatory,anticoagulants,antibacterial and antifungals.In this study,the advances on the antibacterial activity of coumarins were summarized.The main target in medicine is Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,β-hemolytic streptococcus,Haemophilus infuenzae and Vibrio cholera,etc.,in the agricultural areas are concentrated in Ralstonia solanacearum,Phytophthora capsici,Powdery mildew,Botrytis cinerea and Fusarium graminearum,etc.Indeed,the structure-activity relationship and mechanism action of coumarins were analyzed.Coumarins have multiple substitution sites and can used as a kind of lead compound to synthesize more effective coumarin derivatives with widely application values.关键词
香豆素类化合物/抑菌活性/构效关系/作用机理Key words
coumarins/antibacterial activity/structure-activity relationship/mechanism action分类
医药卫生引用本文复制引用
杨亮,姚晓远,丁伟..香豆素类化合物的抑菌活性研究[J].天然产物研究与开发,2018,30(2):332-338,7.基金项目
国家自然科学基金(31572041) （31572041）
中央高校基本业务费项目(XDJK2017D166) （XDJK2017D166）
