燕山大学学报2018，Vol.42Issue(1)：67-74,8.DOI:10.3969/j.issn.1007⁃791X.2018.01.011
丙泊酚闭环控制系统的设计与仿真
Design and simulation of closed-loop control system of propofol
摘要
Abstract
How to achieve accurately and automatically inject anesthetics is a great challenge both in clinic and neural engineering. Employing the computer to simulate the anesthesia process and control performance are valuable for the design of actual control system.The virtual patient library was established to test the ability of the control system,which responds to differences between patients.And Renyi permutation entropy as the depth of anesthesia monitoring index is proposed,according to the changes of Renyi permutation entropy,the control of propofol input speed is changed.For individualized model of patient,the identification is done, and the model predictive controller is designed and used to control the patient based on identification model.The performance of the control system is analyzed by four indexes: error, median performance error, median absolute performance error, wobble.The simulation results show that the system can well track the desired Renyi permutation entropy and maintain the desired depth of anesthesia.关键词
药代药效动力学/Renyi排序熵/模型预测控制/麻醉闭环控制系统Key words
pharmacokinetics-pharmacodynamics/Renyi permutation entropy/model predictive control/closed-loop anesthetic delivery system分类
信息技术与安全科学引用本文复制引用
梁振虎,李晓宇,苏翠..丙泊酚闭环控制系统的设计与仿真[J].燕山大学学报,2018,42(1):67-74,8.基金项目
国家自然科学基金资助项目(61673333) （61673333）
