中国病理生理杂志2018，Vol.34Issue(3)：572-576,5.DOI:10.3969/j.issn.1000-4718.2018.03.032
外泌体在缺血性脑卒中的研究进展
Advance of exosomes in ischemic stroke
摘要
Abstract
Stroke is one of the major causes of death and disability in China and even worldwide.At present, treatment of stroke has been traditionally focused on reducing death of ischemic cells.However,clinical trials have shown that none of neuroprotective drugs tested achieve clinical benefit after acute stroke.Exosomes are 30~100 nm extracellular vesicles derived from cells with cell membrane structure.Many studies suggest exosomes play essential roles in intercellular communication by transferring their cargo between source and target cells in brain.Emerging data show that exsomes also make a contribution to brain recovery via regulating highly interactive process pathway after stroke.Here,we review these advances and highlight the potential therapeutic functions of exosomes in brain remodeling after stroke.关键词
外泌体/脑卒中/神经保护/神经治疗Key words
Exosome/Stroke/Neuroprotection/Neurotherapy分类
医药卫生引用本文复制引用
柴毅,纪晨星,祝新根,高子云..外泌体在缺血性脑卒中的研究进展[J].中国病理生理杂志,2018,34(3):572-576,5.基金项目
国家自然科学基金项目项目(No.81660420) （No.81660420）
江西省优势科技创新团队建设计划项目(No.20152BCB24009) （No.20152BCB24009）
