中国感染控制杂志2018，Vol.17Issue(4)：277-282,6.DOI:10.3969/j.issn.1671-9638.2018.04.001
白血病患儿血培养病原菌分布、耐药特征及死亡危险因素
Distribution,antimicrobial resistance of pathogens from blood culture,and risk factors for death of children with leukemia
摘要
Abstract
Objective To observe distribution and antimicrobial resistance of pathogens from blood culture of chil-dren with leukemia,and study risk factors.Methods From September 2013 to November 2016,species and antimi-crobial resistance types of 131 strains of pathogens isolated from blood culture of 110 children in a pediatric hemato-logy ward were analyzed,childrens'clinical data were also analyzed statistically.Results 131 strains(5.23%)of pathogens were isolated from 2 505 blood culture specimens,gram-negative bacilli and gram-positive cocci accounted for 52.67% and 43.51% respectively,the top 3 pathogens were Escherichia coli(15.27%),Klebsiella pneumoniae (15.27%),and Staphylococcus hominis(12.98%). Gram-negative bacilli were highly resistant to ampicillin,ce-fazolin,ceftriaxone,and ampicillin/sulbactam,but sensitive to amikacin,cefoperazone/sulbactam,piperacillin/tazobactam,and carbapenems;gram-positive cocci had higher resistance to penicillin,oxacillin,erythromycin,and clindamycin,but were sensitive to tigecycline,linezolid,vancomycin,and quinupristin/dalfopristin. Univariate analysis showed that mixed infection,diarrhea,Pseudomonasaeruginosa infection,and Acinetobacterbaumannii in-fection were related to mortality due to bloodstream infection in children with leukemia.Conclusion Pathogens cau-sing bloodstream infection in children with leukemia is widely distributed,antimicrobial resistance rate is high,it is very im-portant to take active precaution and rational treatment according to antimicrobial susceptibility testing result.关键词
儿童/白血病/血培养/耐药性/抗药性,微生物/死亡危险因素Key words
child/leukemia/blood culture/drug resistance/microbial/risk factor for death分类
医药卫生引用本文复制引用
刘宁,赵娟,李艳明,晏群,钟一鸣,杨芳,刘文恩..白血病患儿血培养病原菌分布、耐药特征及死亡危险因素[J].中国感染控制杂志,2018,17(4):277-282,6.基金项目
国家自然科学基金资助项目(81672066) （81672066）
