中国感染控制杂志2018，Vol.17Issue(4)：304-309,6.DOI:10.3969/j.issn.1671-9638.2018.04.006
1061株血标本分离菌的分布及耐药性
Distribution and antimicrobial resistance of 1 061 pathogenic strains isola-ted from blood specimens
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance of pathogens isolated from blood specimen,and provide laboratory basis for clinical treatment of bloodstream infection. Methods Pathogens isolated from blood specimen in a hospital laboratory from January 1,2015 to December 31,2016 were identified and per-formed antimicrobial susceptibility testing.Results A total of 1 061 pathogenic strains were isolated from blood speci-men,of which gram-negative bacillus,gram-positive coccus,and fungus accounted for 53.35%(n= 566),36.10%(n=383),and 10.55%(n= 112)respectively,the major gram-negative bacillus,gram-positive coccus,and fungus were Escherichia coli(E.coli)and Klebsiella pneumoniae(K.pneumoniae),coagulase-negative Staphylococcus,and Candida parapsilosis respectively. Strains were mainly isolated from intensive care unit(ICU,n= 308,29.03%),followed by hematology department and pediatric internal medicine department. Resistance rates of E.coli and K. pneumoniae to imipenem were 2.65% and 40.12% respectively.Extended-spectrum beta-lactamase(ESBL)-produ-cing E.coli and K.pneumoniae accounted for 62.96% and 33.14% respectively. Linezolid- and vancomycmin-re-sistant Staphylococcusspp. Were not found,isolation rates of methicillin-resistant coagulase-negative Staphylococ-cus and methicillin-resistant Staphylococcus aureus were 83.61% and 45.45% respectively,one vancomycin-resis-tant Enterococcus faeciu m and one linezolid-resistant Enterococcus faecium were isolated respectively.Conclusion There are multiple species of pathogens isolated from blood specimen,distribution and antimicrobial resistance of pathogens casing bloodstream infection should be monitored regularly to guide the empiric antimicrobial therapy.关键词
血标本/血流感染/抗菌药物/耐药性/抗药性，微生物/合理用药Key words
blood specimen/bloodstream infection/antimicrobial agent/drug resistance/microbial/rational drug use分类
医药卫生引用本文复制引用
郭小兵,饶玉婷,贺小红,田富云,胡晓欣,任益慧,刘娜..1061株血标本分离菌的分布及耐药性[J].中国感染控制杂志,2018,17(4):304-309,6.基金项目
河南省科技厅科技攻关项目(162102310509) （162102310509）
