中国感染控制杂志2018，Vol.17Issue(4)：310-315,6.DOI:10.3969/j.issn.1671-9638.2018.04.007
实施抗菌药物管理提高铜绿假单胞菌对碳青霉烯类药物的敏感性
Implementing antimicrobial management toimprove susceptibility of Pseudom onas aeruginosa to carbapenems
王瑶 1王宏志 2李琪 1刘琳娟 1王广发1
作者信息
- 1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
- 2. 北京大学国际医院,北京 102206
- 折叠
摘要
Abstract
Objective To analyze susceptibility of clinically isolated Pseudomonas aeruginosa(PA)to carbape-nems,and observe the effect of classified management of antimicrobial agents on carbapenem susceptibility.Methods PA isolated from Peking University Cancer Hospital between October 2012 and March 2014 were collected,uni-variate analysis and multivariate logistic regression analysis were adopted to study the risk factors for non-suscepti-bility to carbapenems,susceptibility of PA to carbapenems before and after the implementation of classified manage-ment of antimicrobial agents was analyzed.Results A total of 125 strains of PA were isolated,mainly from patients with esophageal cancer(n=30,24.0%)and colorectal cancer(n=29,23.2%);the main specimens were drainage fluid and wound secretion(n=62,49.6%);the main source departments were surgical wards(n=86,68.8%). Univariate analysis showed that non-susceptibility of PA to carbapenems was related to strains from surgical wards,hospitalization within 3 months,carbapenem exposure,and length of hospital stay>4 weeks. Logistic regression analysis showed that 3 independent risk factors were:strains from surgical wards,exposure to carbapenems,and length of hospital stay>4 weeks. Susceptibility of PA to carbapenems after implementation of antimicrobial man-agement was 74.6%,which was higher than 53.4% before management(P= 0.015).Conclusion Strains from surgical wards,carbapenem exposure,and length of hospital stay>4 weeks are independent risk factors for no-sus-ceptibility of PA to carbapenems;susceptibility of PA to carbapenems is increased after strict implementation of antimicrobial classified management system.关键词
铜绿假单胞菌/碳青霉烯/抗菌药物/分级管理制度/抗菌药物管理Key words
Pseudomonas aeruginosa/carbapenem/antimicrobial agent/classified management system/antimi-crobial management分类
医药卫生引用本文复制引用
王瑶,王宏志,李琪,刘琳娟,王广发..实施抗菌药物管理提高铜绿假单胞菌对碳青霉烯类药物的敏感性[J].中国感染控制杂志,2018,17(4):310-315,6.
