中国免疫学杂志2018，Vol.34Issue(3)：454-459,6.DOI:10.3969/j.issn.1000-484X.2018.03.028
干扰素刺激基因及临床意义研究进展
Research progress towards interferon stimulated genes and its clinical signifi-cance
摘要
Abstract
Interferon (IFN) acts on the surface of the target cell receptors and activate the expression of interferon stimulated genes(interferon stimulated genes,ISGs) through a series of signal transduction.ISGs have antiviral and immunomodulation and other biological functions,indicating ISGs are important molecules for interferon to function and have some potential clinical significance.A large number of research results showed that ISGs may predict the antiviral effect of IFN-α;specific expression of ISGs in patients with autoimmune diseases in vivo may be used as a new biomarker for clinical diagnosis of the diseases;ISGs may act as a new target for cancer treatment and have other potential applications.This review mainly focuses on the induction,the biological functions like antiviral effects and the potential clinical significance of ISGs.关键词
干扰素刺激基因/抗病毒效应/免疫调控Key words
Interferon stimulated genes/Antiviral effect/Immunomodulation分类
医药卫生引用本文复制引用
刘洋,刘永亮,葛胜祥..干扰素刺激基因及临床意义研究进展[J].中国免疫学杂志,2018,34(3):454-459,6.基金项目
本文受国家自然科学基金面上项目(81672111)资助. （81672111）
