中国免疫学杂志2018，Vol.34Issue(3)：472-477,6.DOI:10.3969/j.issn.1000-484X.2018.03.032
pMHC多聚体技术研究进展
Recent advances in pMHC multimer technology
摘要
Abstract
To overcome the intrinsic low affinity between peptide bound major histocompatibility complex(pMHC) and T cell receptors (TCRs) on T cell surface,pMHC can be multimerized to enhance its avidity to TCRs.Since 20 years ago pMHC tetramer was first applied in the detection of antigen specific T cells,it has become one of the most important immunoassay tools.Recently,pMHC multimers have been significantly improved over the original tetramer.pMHC multimers with higher valence have been produced in order to enhance detection sensitivity.Additionally,reversible pMHC multimers,which can be released from T cell surface to avoid potential damage to T cells,also have been applied in the isolation of antigen specific T cells.As a class of molecular tools,pMHC multimers play an important role in immunoassays and immunotherapies.A good knowledge and effective utilization of those tools will be greatly helpful in scientific and clinical applications.关键词
MHC/四聚体/多聚体/TCR/免疫治疗Key words
MHC/Tetramer/Multimers/TCR/Immunotherapy分类
医药卫生引用本文复制引用
董帅,郑红俊,钟时..pMHC多聚体技术研究进展[J].中国免疫学杂志,2018,34(3):472-477,6.基金项目
本文受广东省引进创新创业团队计划资助(No.201301S0105473152). （No.201301S0105473152）
