中国全科医学2018，Vol.21Issue(5)：521-525,5.DOI:10.3969/j.issn.1007-9572.2017.00.259
2型糖尿病肥胖或超重患者血清成纤维细胞生长因子21水平及其临床价值研究
Clinical Significance of Fibroblast Growth Factor 21 Levels for Obese or Overweight Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the levels of serum fibroblast growth factor 21 (FGF21) in obese or overweight patients with type 2 diabetes mellitus (T2DM),and to explore its correlation with body mass index (BMI) and HOMA-insulin resistance index (HOMA-IR). Methods Patients of 213 cases with T2DM who were hospitalized in the Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University from January 2014 to July 2016 were selected and subsequently divided into a T2DM obesity and overweight group (BMI≥24.0 kg/m2,127 cases),and a T2DM non-obesity or overweight group (BMI<24.0 kg/m2,86 cases) according to BMI. Healthy individuals in the same periods were selected as the control group (114 cases). A range of parameters were recorded,including blood pressure,BMI, total cholesterol (TC),triglyceride (TG),high density lipoprotein-cholesterol (HDL-C),low density lipoprotein-cholesterol (LDL-C),HbA1c,fasting blood glucose (FBG),fasting insulin (FINS),HOMA-insulin resistance index (HOMA-IR) and FGF21. Results Diastolic blood pressure (DBP),body mass,BMI,TG,HDL-C,LDL-C, HbA1c,FBG,FINS,HOMA-IR were significantly different among the three groups (P<0.05). FGF21 level in the T2DM non-obese or overweight group was higher than that in the control group (P<0.05). FGF21 level in the obesity and overweight T2DM group was higher than that in the control group,T2DM non-obese or overweight group (P<0.05). Spearman correlation analysis showed that,the level of serum FGF21 was positively correlated with BMI,FINS and HOMA-IR in obesity and overweight T2DM group (rs=0.312,0.311,0.243,P<0.05). Multivariate linear regression analysis showed that BMI 〔b=3.654,95%CI(1.543,5.764)〕,FINS〔b=1.310,95%CI(0.537,2.082)〕 were shown to be factors which influenced FGF21 levels in the obesity and overweight T2DM group (P<0.05). Conclusion Serum FGF21 levels were higher in the T2DM obesity and overweight patients,and were related to BMI,IR and other factors. Serum FGF21 may be used to predict the occurrence of diabetes and obesity,and represents a target for the development of a new generation of drugs for the treatment of diabetes and obesity.关键词
糖尿病,2型/肥胖症/成纤维细胞生长因子21/体脂肪率/胰岛素抵抗Key words
Diabetes mellitus,type 2/Obesity/Fibroblast growth factors 21/Adiposity/Insulin resistance分类
医药卫生引用本文复制引用
张楠,姜天,孙莉,代芳,章秋..2型糖尿病肥胖或超重患者血清成纤维细胞生长因子21水平及其临床价值研究[J].中国全科医学,2018,21(5):521-525,5.基金项目
国家自然科学基金青年科学基金培养计划(2013KJ15) （2013KJ15）
安徽省自然科学基金青年基金(1608085QH205) （1608085QH205）
