摘要
Abstract
Objective To observe the effects of nutrient enrichment with glutamine on intestinal permeability and infectious complications after left colonic resection.Methods We enrolled 80 cases of colon cancer receiving left colonic resection in Cangzhou Central Hospital from August 2013 to June 2016 and divided them into the control group and observation group,with 40 cases in each based on the random numbers table.Both groups received the conventional enteral nutrition,the observation group additionally received nutrient enrichment with glutamine. The outcome indexes were compared between two groups,including intestinal permeability indexes〔urinary lactulose/mannitol test(L/M),plasma diamine oxidase(DAO), D-lactic acid,tumor necrosis factor α(TNF-α)〕,nutritional indexes(serum albumin and prealbumin),time needed to recover the bowel sound,duration of hospitalization and rate of infectious complications.Results The values of urinary L/M, plasma DAO,D-lactic acid and TNF-α measured on the 2nd,7th days after surgery were higher than those measured on the day before surgery in both groups(P<0.05).The values of urinary L/M,plasma DAO,D-lactic acid and TNF-α measured on the 7th day after surgery were found to be lower than those measured on the 2nd day after surgery in both groups(P<0.05). The observation group demonstrated lower values of urinary L/M,plasma DAO,D-lactic acid and TNF-α than the control group on the 2nd day as well as the 7th day after surgery(P<0.05).In the control group,the values of albumin and prealbumin measured on the day before surgery were all higher than those measured on the 2nd,7th days after surgery(P<0.05),and the values of albumin and prealbumin measured on the 7th day after surgery were higher than those measured on the 2nd day after surgery(P<0.05).In the observation group,the values of albumin and prealbumin measured on the day before surgery were all higher than those measured on the 2nd day after surgery(P<0.05),and the values of albumin and prealbumin measured on the 7th day after surgery were higher than those measured on the 2nd day after surgery(P<0.05).The observation group presented higher values of albumin and prealbumin than the control group on the 2nd day as well as the 7th day after surgery (P<0.05).The observation group needed shorter time to recover the bowel sound and had shorter duration of hospitalization compared with the control group (P<0.05).The rate of infectious complications in the observation group was lower than that in the control group〔7.5%(3/40)vs 27.5%(11/40)〕(χ2=5.486,P=0.019).Conclusion For patients receiving left colonic resection,nutrient enrichment with glutamine based on the conventional enteral nutrition can maintain the permeability of intestinal mucosa,protect the function of intestinal mucosal barrier and reduce the incidence of infectious complications.关键词
结肠切除术/谷氨酰胺/肠通透性/感染并发症Key words
Colectomy/Glutamine/Intestinal permeability/Infectious complications分类
医药卫生
