中国全科医学2018，Vol.21Issue(5)：531-534,4.DOI:10.3969/j.issn.1007-9572.2017.00.173
肠内免疫营养对急性重型颅脑损伤患者免疫功能及预后的影响研究
Effects of Immunomodulating Enteral Nutrition on the Immunologic Function and Prognosis of Patients with Acute Severe Craniocerebral Injury
摘要
Abstract
Objective To evaluate the effect of immunomodulating enteral nutrition on T-lymphocyte subset, mechanical ventilation and prognosis in patients with acute severe craniocerebral injury.Methods Seventy-two patients with acute severe craniocerebral injury treated in the ICU,the Affiliated Hospital of Hangzhou Normal University from August 2014 to February 2016 were selected as the subjects and randomly divided into the treatment group and the control group,with 36 in each.The treatment group received enteral nutritional emulsion (TPF-T),and the control group received homogenate(a kind of enteral nutritional suspension) with the same amount of nitrogen and calories contained in TPF-T given to the treatment group. The duration of mechanical ventilation,rate of successful weaning from mechanical ventilation within two weeks after treatment were recorded.T-lymphocyte subset were measured on the 1st,7th,14th days after admission.And the neurological function was evaluated by the Glasgow Outcome Score(GOS)at 6 months after treatment.Results The treatment group had shorter duration of mechanical ventilation and higher rate of successful weaning from mechanical ventilation within 2 weeks after treatment than the control group (P<0.05).On the 7th,14th days after admission,the levels of CD+3,CD+4and CD+4/CD+8were all significantly higher in the treatment group than in the control group (P<0.05).The overall GOS and average GOS assessed at 6 months after treatment were all better in the treatment group than in the control group (P<0.05).Conclusion The timely and reasonable immunomodulating enteral nutrition can improve the immune function,shorten the duration of mechanical ventilation,increase the rate of successful weaning from mechanical ventilation and promote the recovery of neurological function among the patients with acute severe craniocerebral injury.关键词
颅脑损伤/肠内免疫营养/T淋巴细胞亚群/呼吸,人工/格拉斯哥预后评分Key words
Craniocerebral trauma/Immunomodulating enteral nutrition/T-lymphocyte subsets/Respiration,artificial/Glasgow outcome scale分类
医药卫生引用本文复制引用
王白永,林乐清,唐文学..肠内免疫营养对急性重型颅脑损伤患者免疫功能及预后的影响研究[J].中国全科医学,2018,21(5):531-534,4.基金项目
浙江省中医药科技计划项目(2016ZB103) （2016ZB103）
