中国全科医学2018，Vol.21Issue(8)：993-997,5.DOI:10.3969/j.issn.1007-9572.2017.00.262
邻苯二甲酸二(2-乙基)己酯与胰岛素抵抗的研究进展
Research Progress on Di-(2-ethylhexyl) Phthalate and Insulin Resistance
摘要
Abstract
Di-(2-ethylhexyl) phthalate(DEHP) is a plasticizer that is widely distributed in the environment. Epidemiological studies have shown that DEHP exposure is associated with insulin resistance,which in turn affects the occurrence of type 2 diabetes as well as metabolic syndrome.DEHP leads to insulin resistance through the insulin signaling pathway,the transcription factor peroxisome proliferators-activated receptor gamma (PPAR-γ) pathway,oxidative stress, lysosome-mitochondrial axis pathways and other metabolic risk factors.关键词
胰岛素抵抗/二乙基己基邻苯二甲酸/胰岛素敏感性/胰岛素信号转导Key words
Insulin resistance/Diethylhexyl phthalate/Insulin sensitivity/Insulin signaling pathway分类
医药卫生引用本文复制引用
张敏,何继瑞..邻苯二甲酸二(2-乙基)己酯与胰岛素抵抗的研究进展[J].中国全科医学,2018,21(8):993-997,5.基金项目
甘肃省自然科学基金资助项目(1308RJZA246) （1308RJZA246）
