中国比较医学杂志2018，Vol.28Issue(3)：21-27,7.DOI:10.3969/j.issn.1671-7856.2018.03.004
物体认知——基于动物自发行为的一种学习记忆评价方法的研究
Object recognition test—a method to assess the learning and memory in mice based on their spontaneous behavior
摘要
Abstract
Objective To develop a multi-mode,detailed and sensitive object recognition method for learning and memory research,including novel object recognition task,object location recognition task,temporal order memory task and object context recognition task in animals based on their spontaneous behavior. Methods Two strains of mice(KM and ICR)and four patterns were used to establish the object recognition method and several relative factors,such as time of test phase,delay between test phase and familiar phase were investigated. Results It was stable and reasonable to set the time of familiar phase as 5 min,the interval between test phase and familiar phase as 10 min,and the time of test phase as 3-5 min,under the precondition of habituation for three days and selecting the appropriate object pairs. Conclusions Object recognition test including four patterns has been systematically established as a stable, reliable and normative way for the research of animal learning and memory and drug development.关键词
物体认知/物体位置/时序记忆/情景记忆/学习记忆/小鼠Key words
object recognition/object location/temporal order/object context/learning and memory/mice分类
医药卫生引用本文复制引用
吕静薇,宋广青,董黎明,姜宁,陈善广,刘新民..物体认知——基于动物自发行为的一种学习记忆评价方法的研究[J].中国比较医学杂志,2018,28(3):21-27,7.基金项目
中国医学科学院创新工程(编号:2016-I2M-2-006) （编号:2016-I2M-2-006）
国家重点研发计划政府间国际科技合作重点专项(编号:2016YFE0131800). （编号:2016YFE0131800）
