中国实用儿科杂志2018，Vol.33Issue(2)：105-109,5.DOI:10.19538/j.ek2018020606
先天性肾积水与肾间质纤维化研究进展
Research progress in congenital nephrosis and renal interstitial fibrosis
摘要
Abstract
Congenital abnormalies of the kidney and urinary tract (CAKUT) are the main cause of chronic kidney disease (CKD)in childhood.Congenital hydronephrosis is a common type of CAKUT and is usually detected by prenatal renal ultrasonography.Severe congenital nephrosis can cause renal injury and end-stage renal disease (ESRD).The etiology of congenital nephrosis is complicated and involves the abnormal expression of multiple genes.Studies on human tissue specimens and animal models show that oxidative stress,chronic inflammation and apoptosis result in renal tubular atrophy and renal fibrosis.With advanced biological techniques such as proteomics,new biological markers are emerging for early disease detection and the choice of the optimal treatment and monitoring.关键词
先天性肾积水/肾纤维化/慢性肾脏疾病/肾盂输尿管连接处梗阻Key words
congenital nephrosis/renal fibrosis/chronic renal disease/ureteropelvic junction obstruction分类
医药卫生引用本文复制引用
王秀丽,吴玉斌..先天性肾积水与肾间质纤维化研究进展[J].中国实用儿科杂志,2018,33(2):105-109,5.基金项目
辽宁省科学技术计划重大项目(2013225086) （2013225086）
