中国实用儿科杂志2018，Vol.33Issue(2)：117-121,5.DOI:10.19538/j.ek2018020609
线粒体相关性肾脏病的认识
Mitochondria-associated nephropathy
张爱华 1车若琛1
作者信息
- 1. 南京医科大学附属儿童医院肾脏科,江苏南京210008
- 折叠
摘要
Abstract
Mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases,which can be divided into inherited mitochondrial cytopathy and acquired mitochondrial dysfunction.Mitochondrial cytopathy involves mtDNA point mutations,fragment deletion and rearrangements,mtDNA depletions and nuclear genes mutations.Acquired mitochondrial dysfunction refers to oxidative phosphorylation disorder and decrease of mtDNA copy number due to various causes.All the above-mentioned might induce podocytes injury,tubular dysfunction,interstitial nephropathy,cystic renal diseases as well as carcinoma.At present,the therapy for mitochondrial cytopathy is still deficient.Genetic therapy and mitochondria-targeted protective agents may offer potential treatments for renal diseases.关键词
线粒体细胞病/线粒体功能障碍/肾脏Key words
mitochondrial cytopathy/mitochondrial dysfunction/kidney分类
医药卫生引用本文复制引用
张爱华,车若琛..线粒体相关性肾脏病的认识[J].中国实用儿科杂志,2018,33(2):117-121,5.
