中国听力语言康复科学杂志2018，Vol.16Issue(1)：10-13,4.DOI:10.3969/j.issn.1672-4933.2018.01.003
高危神经母细胞瘤综合治疗患儿远期听力结果调查
The Long Term Hearing Results of the High-risk Neuroblastoma Children with Comprehensive Treatment
蒋浩贤 1刘媛媛 2张安安 3卢宇涵 4顾宇 1高怡瑾 3陈洁 1周敏3
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心耳鼻咽喉科 上海 200127
- 2. 北京市普仁医院耳鼻喉科 北京 100069
- 3. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 上海 200127
- 4. 英国南安普顿大学 南安普顿 SO171BJ
- 折叠
摘要
Abstract
Objective To observe the long-term hearing development of children with high-risk NB after comprehensive treatment.Methods 19 children (38 ears) with high-risk NB who were received comprehensive treatment in our hospital, in the first time before chemotherapy (Ⅰ period)were selected, the last time after chemotherapy (Ⅱ period) and five years after treatment (Ⅲ period),they received standardized audiological examination,including the acoustic immittance(226 or 1000 Hz),PTA,DPOAE and ABR,age matched.Results Patients with varying degrees of hearing loss in Ⅱ and Ⅲ periods, and the number of the patients at period Ⅱ with ABR threshold abnormal is less than those at period Ⅲ with pure tone audiometry abnormal, but there was no significant difference between the results of DPOAE, Period Ⅲ, DPOAE frequency and pure tone audiometry increased the frequency of abnormal matching.Conclusions For children with high-risk NB comprehensive treatment,early ABR results can fully reflect the hearing loss, and also the best reference to the results of DPOAE,and regular hearing follow-up plans should be established.关键词
神经母细胞瘤/纯音测听/畸变产物耳声发射Key words
Neuroblastoma/Pure-tone threshold/Distortion product otoacoustic emission引用本文复制引用
蒋浩贤,刘媛媛,张安安,卢宇涵,顾宇,高怡瑾,陈洁,周敏..高危神经母细胞瘤综合治疗患儿远期听力结果调查[J].中国听力语言康复科学杂志,2018,16(1):10-13,4.
