中国药科大学学报2018，Vol.49Issue(1)：1-9,9.DOI:10.11665/j.issn.1000 -5048.20180101
蛋白酪氨酸磷酸酶1B及其抑制剂的研究进展
Advances in research of protein tyrosine phosphatase 1B and its inhibitors
摘要
Abstract
Protein tyrosine phosphatase 1B(PTP1B),a member of protein tyrosine phosphatases(PTPs),plays a key role in the negative regulation of insulin and leptin signalings.Recent studies showed that PTP1B had an important connection with endoplasmic reticulum(ER)stress, pancreatic beta cells proliferation and insulin secretion,and is closely related to the pathological process of type 2 diabetes mellitus(T2DM)and obesity. Therefore,PIP1B targeted inhibitors have become a research hotspot in the treatment of these metabolic disea-ses.Based on the structural features of PTP1B and its relationship with T2DM and obesity,PTP1B inhibitors were classified according to the sites of binding.Their latest research advances were reviewed in this paper,providing a reference for the development of anti-T2DM and anti-obesity drugs targeting PTP1B.关键词
蛋白酪氨酸磷酸酶1B/2型糖尿病/肥胖症/抑制剂/进展Key words
protein tyrosine phosphatase 1B/type 2 diabetes mellitus/obesity/inhibitors/progress分类
医药卫生引用本文复制引用
袁仲,陈卓,李乾斌,胡高云..蛋白酪氨酸磷酸酶1B及其抑制剂的研究进展[J].中国药科大学学报,2018,49(1):1-9,9.基金项目
国家自然科学基金资助项目(No.81573287)This study was supported by the National Natural Science Foundation of China(No.81573287) （No.81573287）
