中国药科大学学报2018，Vol.49Issue(1)：10-19,10.DOI:10.11665/j.issn.1000 -5048.20180102
具有多靶点抗阿尔茨海默病活性的黄酮类化合物研究进展
Research advances of multi-targeted flavonoids in the intervention of Alzhei-mer's disease
摘要
Abstract
Alzheimer′s disease(AD)is a chronic progressive neurodegenerative disease in the elderly,which causes heavy burden for the society and family.The current drugs could only improve the cognitive symptoms in the short term,but could not reverse or stop the disease progression.In view of the complexity of AD,multi-targe-ted drugs could be a potential strategy for the treatment of AD.Flavonoids,widely exising in the natural world, have multiple pharmacological activities.This paper summarizes flavonoids as promising multi-targeted anti-AD candidates according to the reported references previonsly published,which could provide important evidences in the development of anti-AD durgs.关键词
阿尔茨海默病/多靶点导向药物/黄酮类化合物Key words
Alzheimer′s disease/multi-target directed ligands/flavonoids分类
医药卫生引用本文复制引用
袁丽娟,王柯人,桑志培..具有多靶点抗阿尔茨海默病活性的黄酮类化合物研究进展[J].中国药科大学学报,2018,49(1):10-19,10.基金项目
河南省基础与前沿技术研究计划资助项目(No.162300410103) （No.162300410103）
河南省高等学校重点科研资助项目(No.17B350002) （No.17B350002）
南阳师范学院专项科研资助项目(No.ZX2016017)This study was supported by the Basic and Frontier Technology Research Program of Henan Province( No. 162300410103) （No.ZX2016017）
the Key Scientific Research Project of College （）
