中国药理学通报2018，Vol.34Issue(3)：303-308,6.DOI:10.3969/j.issn.1001-1978.2018.03.002
糖尿病认知功能障碍的机制及中药干预研究进展
Pathogenesis of diabetic cognitive dysfunction and intervention by traditional Chinese medicine
摘要
Abstract
Diabetic cognitive dysfunction (DCD) is a common chronic complication of diabetes mellitus with sophisticated path-ogenesis which has not yet been fully elucidated. In this review paper, the mechanisms of metabolic abnormalities, insulin re-sistance,endoplasmic reticulum stress,neuronal calcium dysho-meostasis, in ammation, blood brain barrier impairment, and mitochondrial injury associated with DCD are reviewed. In addi-tion,the prevention and treatment of DCD by traditional Chinese medicines (TCMs) and the effective compounds are comprehen-sively summarized, in order to provide an updated overview on the DCD pathogenesis,as well as the scientific evidence under-pinning the use of TCM interventions for the treatment and pre-vention of DCD.关键词
糖尿病/认知功能障碍/发病机制/代谢异常/中药/治疗和预防Key words
diabetes mellitus/cognitive dysfunction/pathogen-esis/metabolic abnormalities/traditional Chinese medicine/treatment and prevention分类
医药卫生引用本文复制引用
翟亚东,孙桂波,吴咏梅,叶田园,孟祥宝,孙晓波..糖尿病认知功能障碍的机制及中药干预研究进展[J].中国药理学通报,2018,34(3):303-308,6.基金项目
国家科技部"重大新药创制"科技重大专项(No 20172X09101003-009) （No 20172X09101003-009）
协和青年基金资助项目(No 3332016076) （No 3332016076）
