中国药理学通报2018，Vol.34Issue(3)：309-312,4.DOI:10.3969/j.issn.1001-1978.2018.03.003
以DJ-1蛋白为靶点治疗肝纤维化的研究进展
Progress of DJ-1 protein as target for liver fibrosis treatment
摘要
Abstract
Liver fibrosis occurs prior to cirrhosis and the patho-logical feature is the transitional deposition of extracellular matrix and activation of hepatic stellate cells. Varieties of cytokines and related signaling pathways have been shown to participate in the process of hepatic fibrosis or activation of hepatic stellate cells. In recent years,studies have emerged to reveal the role of tran-scriptional factor DJ-1 in hepatic fibrosis. DJ-1 can relieve the process of hepatic fibrosis by regulating the level of oxidative free radicals in hepatocytes,Kupffer cells and inflammatory cell infil-suggesting DJ-1 as a potential molecular target for hepatic fibrosis treatment. This article provides a comprehensive review of DJ-1 in hepatic fibrosis treatment, including liver fibrosis and oxidative stress, DJ-1 structure and function, mechanism of DJ-1 in the treatment of hepatic fibrosis, and therapeutic prospect of targeting DJ-1.关键词
DJ-1/肝纤维化/氧化应激/肝实质细胞/肝Kupffer细胞/肝星状细胞/中性粒细胞浸润Key words
DJ-1/liver fibrosis/oxidative stress/liver paren-chymal cells/Kupffer cells/hepatic stellate cells/inflammatory cells infiltration分类
医药卫生引用本文复制引用
李军,陈攀,陈孝,陈杰..以DJ-1蛋白为靶点治疗肝纤维化的研究进展[J].中国药理学通报,2018,34(3):309-312,4.基金项目
国家自然科学基金资助项目(No 81503156,81601347) （No 81503156,81601347）
广东省自然科学基金资助项目(No 2015A030313021) （No 2015A030313021）
广东省自然科学基金博士启动项目(No 2014A030310096) （No 2014A030310096）
广东省公益基金项目(No 2016A020218006) （No 2016A020218006）
