中国药理学通报2018，Vol.34Issue(3)：312-315,4.DOI:10.3969/j.issn.1001-1978.2018.03.004
益生菌预防肿瘤作用研究进展
Review research on tumor prevention of probiotics
摘要
Abstract
Recently,research on microbes has been explored ex-plosively. Microbial-related studies have become the forefront of anti-cancer research. A large number of microorganisms are uni-versal in the viscera, skin, nose, mouth and reproductive sys-tem. Probiotics is a kind of microorganisms beneficial to human health. Although most studies have proven the tumor-promoting effects of bacterial flora,antitumor effects of probiotics have also been observed. Studies have confirmed that probiotics can pre-vent the onset of early stage colon cancer as well as non-colorec-tal cancer mainly via several mechanisms,such as adjustment of intestinal flora,regulation of immune response,anti-inflammato-inactivation of metabolic carcinogen, antioxidant and induction of tumor cell apoptosis. However,the specific underlying molecular mechanism still needs to be further studied. The latest studies on human have shown that intestinal microbiota combining with diet can alter the risk of special colorectal cancer. As a cancer chemoprevention strategy, more pre-clinical and clinical research are in need for the study of the effects of probiotics on cancer prevention and treatment.关键词
微生物/益生菌/肠道菌群/肿瘤预防/作用机制/免疫调节Key words
microbiota/probiotics/intestinal flora/tumor pre-vention/mechanism/immunoregulation分类
医药卫生引用本文复制引用
王爱云,沈颖,仲金秋,张婷婷,陈文星,孙志广,陆茵..益生菌预防肿瘤作用研究进展[J].中国药理学通报,2018,34(3):312-315,4.基金项目
国家自然科学基金资助项目(No 81573859,81673795) （No 81573859,81673795）
江苏省自然科学基金资助项目(No BK20151567) （No BK20151567）
2013年江苏高校优秀科技创新团队计划[苏教科(2013)10号文] （2013）
江苏高校品牌专业建设工程资助项目 ( No PPZY2015A070) （ No PPZY2015A070）
江苏高校中药学优势学科建设工程资助项目(PAPD)[苏政办发(2014)37号文] （PAPD）
