中国药理学通报2018，Vol.34Issue(3)：316-321,6.DOI:10.3969/j.issn.1001-1978.2018.03.005
高原缺氧对药物转运体影响的研究进展
Advances of studies on effect of drug transporter under hypoxia
摘要
Abstract
Plateau environment has the characteristic of low ox-ygen and low pressure, which leads to a series of physiological changes and affects the process of drug metabolism in the body. Many factors affect the pharmacokinetic parameters, including gastric emptying, blood rheology, cardiopulmonary function, hepatorenal function, cytochrome P450 enzyme and so on. The present study focuses on drug metabolic enzymes, since drug transporter is the key factor that mediates drugs in their entrance to the body through the cell membrane, producing the curative effect. In order to provide the reference to further research on the effect of plateau hypoxia on pharmacokinetics and guide the rational use of drugs, we review in this paper the classification of the transporter, mediated drug substrates, the influence of hypoxia on expression levels of drug transporter substrates and the regulatory mechanism of drug transporter under the condition of hypoxia.关键词
缺氧/药物转运体/组织分布/药物底物/药物代谢/调控机制Key words
plateau hypoxia/drug transporter/organization dis-tribution/drug substrate/drug metabolism/regulation mecha-nism分类
医药卫生引用本文复制引用
张明霞,王荣,李文斌,鹿辉,谢华,罗冰峰,王昌,刘晶晶,贾正平..高原缺氧对药物转运体影响的研究进展[J].中国药理学通报,2018,34(3):316-321,6.基金项目
国家科技部重大项目军队特需药保密专项(No 2008ZXJ09014-010) （No 2008ZXJ09014-010）
国家自然科学基金资助项目(No 81401552,81403004,81673508) （No 81401552,81403004,81673508）
全军后勤科研"十二五"重大项目(No AWS14L0005) （No AWS14L0005）
全军医学科研"十二五"重点项目(No BWS12J012) （No BWS12J012）
甘肃省自然科学基金资助项目(No 145RJZA111,1606RJZA176) （No 145RJZA111,1606RJZA176）
