中国药理学通报2018，Vol.34Issue(3)：437-442,6.DOI:10.3969/j.issn.1001-1978.2018.03.027
高架﹢/〇迷宫实验:经典状态焦虑动物模型相关性研究
Correlation between elevated plus and zero mazes as two animal models of state anxiety in Kunming mice
摘要
Abstract
Aim To explore the correlation between elevated plus maze (EPM) and elevated zero maze (EZM),as two type animal models of state anxiety in Kunming mice. Methods The behavior of adult,♂/♀,Kunming mice in EPM and EZM was recorded by sequence,for 5 min,with a one-week inter-trial interval. The following parameters were evaluated:percentage of time in open arms (Otime%) and total entries into open and closed arms(Entries). Subsequently,descriptive analysis,fac-tor analysis,cluster analysis,correlation analysis and consisten-cy test were calculated for these parameters. Results T test showed that, compared with EPM, Otime% of EZM (male/fe-male/both sex) decreased, while Entries (male/both sex) in-creased significantly;Fiedman test showed that Otime% (male/female/both sex) and Entries(female/both sex) of both EPM and EZM had great difference between the 5 repeated fragments;Wilcoxon test showed that, compared with EPM, Otime% of EZM in 1st min (male/female/both sex), 2nd min (male/fe-male/both sex),3rd min (female/both sex) decreased, while the Entries in 1st min (male/both sex), 4th min (male/fe-male/both sex),5th min(both sex) increased markedly. Clus-ter analysis showed that EPM and EZM parameters could be clustered into two groups:EPM group and EZM group(male/fe-male/both sex). Factor analysis indicated that the EPM and EZM parameters could be extracted as two factors: EPM factor and EZM factor (male/female/both sex). Correlation analysis displayed either general(in Otime%) or poor(in Entries) cor-relation(male/female/both sex) between EPM and EZM param-eters. Consistency test displayed general consistency (male/fe-male/both sex) in Otime% between EPM and EZM. Conclu-sions Despite of the similar internal principles to induce state anxiety,the different external environment(structure) results in different behavioral patterns,different structure dimensions,fair correlation and concordance between EPM and EZM, and the stable index of EPM and EZM might be preferred to Otime%.关键词
高架﹢迷宫实验/高架〇迷宫实验/状态焦虑/动物模型/相关性/昆明小鼠Key words
elevated plus maze (EPM)/elevated zero maze (EZM)/state anxiety/animal model/correlation/Kunming mice分类
医药卫生引用本文复制引用
孙世光,韩兴军,王群,魏盛,乔明琦..高架﹢/〇迷宫实验:经典状态焦虑动物模型相关性研究[J].中国药理学通报,2018,34(3):437-442,6.基金项目
国家科技部"重大新药创制"科技重大专项(No SQ2017ZX090301064) （No SQ2017ZX090301064）
国家自然科学基金资助项目(No 81302887) （No 81302887）
山东省科技发展计划项目 ( No 2014GSF119034) （ No 2014GSF119034）
山东省自然科学基金资助项目(No ZR2014HL099) （No ZR2014HL099）
山东省中医药科技发展计划项目(No 2017-113,2017-115,2015-131,2013-103,2013ZDZK-059) （No 2017-113,2017-115,2015-131,2013-103,2013ZDZK-059）
