浙江农林大学学报2018，Vol.35Issue(2)：367-375,9.DOI:10.11833/j.issn.2095-0756.2018.02.023
丹参酮生物合成分子调控机制的研究进展
Research progress on molecular regulation mechanism involved in the biosynthetic pathway of tanshinone in Salvia miltiorrhiza
摘要
Abstract
Salvia miltiorrhiza, a traditional Chinese herbal medicine, is widely used in preventing and treating cardiovascular diseases. Due to the increasing demand of raw materials of S. miltiorrhiza, its quality has at-tracted more and more attentions. Tanshinone is one of the main pharmacodynamical components. How to make innovations to improve the content of effective pharmacodynamical component and improve the quality of S. miltiorrhiza based on the existing research is an important work for the researchers. In this study, the latest re-search progresses on the cloning and identification of genes and transcription factors involved in the biosynthe-sis pathway of tanshinones, the molecular mechanism of how the elicitors to improve the biosynthesis of tanshi-nones were reviewed. And then the problems of existing research and the future research direction involved in our recent research were also sorted out and discussed. In order to get a comprehensive knowledge about the molecular mechanism on the production of tanshinones, researchers should pay more attention to three key items. Firstly, alternative splicing of key regulatory factors underlying the biosynthesis of tanshinones should be discovered and identified. Secondly, regulation of the biosynthesis of tanshinones medidated by non-coding RNA shoud be paid more attention. Finally, we should pay more efforts to realize the fact of production of tan-shinones using the stratagies of synthetic biology.关键词
植物学/丹参/丹参酮/合成途径/分子机制/综述Key words
botany/Salvia miltiorrhiza/tanshinones/biosynthetic pathway/molecular mechanism/review分类
农业科技引用本文复制引用
李珅,林爱真,杨媛,沈亚芳,饶盈,羊健,刘云辉,王洋,周伟..丹参酮生物合成分子调控机制的研究进展[J].浙江农林大学学报,2018,35(2):367-375,9.基金项目
农业部/浙江省植保生物技术重点实验室开放基金资助项目 （）
国家自然科学基金青年基金资助项目(31501394) （31501394）
浙江农林大学大学生科研训练项目(113-2013200006) （113-2013200006）
