浙江医学2018，Vol.40Issue(1)：3-7,15,6.DOI:10.12056/j.issn.1006-2785.2018.40.1.2017-1717
血清HBV DNA水平及抗病毒治疗对HBV相关性肝细胞癌患者术后预后的影响
Effect of serum HBV DNA and antiviral treatment on prognosis of HBV-related hepatocellular carcinoma following resection
摘要
Abstract
Objective To investigate the effect of serum HBV DNA level and antiviral therapy on the prognosis of HBV-related hepatocellular carcinoma (HCC) following curative resection.Methods Total 701 HBV-related HCC patients who underwent curative resection in Eastern Hepatobiliary Surgery Hospital from October 2009 to August 2010 were enrolled in the study.The association of clinical variables with the prognosis of HCC was analyzed.Results During a follow-up of 64.5months,the HCC recurrence occurred in 450 patients(64.2％) and 217 patients(35.3％) died.Univariate analysis revealed that HBeAg seropositivity,AST＞37 U/L,HBV DNA≥2 000 U/ml,γ-GT＞61 U/L,AKP＞129 U/L,PT＞13 s,AFP＞20 μg/L,tumor number≥2,larger tumor size,cutting margin＜1 cm,no capsule formation,portal vein invasion,microvascular invasion,cirrhosis,higher rank of pTNM stage were associated with a higher cumulative incidence of HCC recurrence.Multivariate analyses showed that HBeAg seropositivity,γ-GT ＞61 U/L,PT ＞ 13s,tumor number ≥2,larger tumor size,portal vein invasion,cutting margin ＜ 1 cm were independently associated with a increased risk of recurrence.For HCC patients with HBV DNA≥2 000 U/ml,the recurrence rate in patients receiving antiviral treatment was lower than those without antiviral treatment (P＜0.01).Conclusion High levels of HBV DNA increased the risk of HCC recurrence following curative resection,and antiviral treatment may reduce the recurrence after curative resection in HCC.关键词
肝细胞癌/复发/抗病毒治疗Key words
Hepatocellular carcinoma/Recurrence/Antiviral treatment引用本文复制引用
李巧媚,周华邦,叶斌,胡和平..血清HBV DNA水平及抗病毒治疗对HBV相关性肝细胞癌患者术后预后的影响[J].浙江医学,2018,40(1):3-7,15,6.基金项目
国家自然科学基金(项目编号:81672371) （项目编号:81672371）
