浙江医学2018，Vol.40Issue(1)：8-11,4.DOI:10.12056/j.issn.1006-2785.2017.40.1.2016-2212
糖尿病肾病患者肾脏组织中尾加压素Ⅱ及转化生长因子β1的表达及意义
Expression of urotensin Ⅱ and TGF-β1 in kidney tissue of patients with diabetic nephropathy and their clinical significance
摘要
Abstract
Objective To investigate the expression of urotensin Ⅱ (U Ⅱ) and TGF-β 1 in kidney tissue of patients with diabetic nephropathy and their clinical significance.Methods 42 People who were diagnosed as diabetic nephropathy by renal biopsy in our hospital from January 2012 to January 2015 were divided into two subgroups based on glomerular pathology classification of Tervaet diabetic nephropathys:subgroup A (n=20) which includes type Ⅰ and type Ⅱ,subgroup B (n=22) which includes type Ⅲ and type Ⅳ,whereas subgroup C (n=15) is normal control group.Expression of U Ⅱ,TGF-β1 in kidney tissue can be detected by immunohistochemical method.Results Urotensin Ⅱ and TGF-β1 are overexpressed in the kidney tissue among patients with diabetic nephropathy,and the expression levels are associated with the disease severity,Indicating that they may play an important role in the development of diabetic nephropathy.Conclusion Expression of UⅡ was positively correlated with the expression of TGF-β1 in glomerulus (r=0.950,P＜0.01)and renal tubule (r=0.963,P＜0.01).The expression of UⅡ and TGF-β1 in diabetic patients was higher than that in normal controls (P＜0.05).In addition,expression of U Ⅱ and TGF-β1 in glomerulus and renal tubule was positively correlated with serum creatinine,urea nitrogen,24-h urine protein,microalbminurine and KatafuChi semi-quantitative chronic integral and total integral,and negatively correlated with the level of eGFR.And the correlation between the expression of U Ⅱ,TGF-β1 and semi-quantitative time delayed integral of eGFR.关键词
尾加压素Ⅱ/转化生长因子β1/糖尿病肾病Key words
Urotensin Ⅱ/TGF-β1/Diabetic nephropathy引用本文复制引用
刘苑苹,李恒,包蓓艳,陈江华..糖尿病肾病患者肾脏组织中尾加压素Ⅱ及转化生长因子β1的表达及意义[J].浙江医学,2018,40(1):8-11,4.基金项目
宁波市卫生局医学科技计划项目(2009B12) （2009B12）
